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Combinatorial Peptide and Nonpeptide Libraries: A Handbook

Combinatorial Peptide and Nonpeptide Libraries: A Handbook

Günther Jung (Editor)

ISBN: 978-3-527-61490-5

Sep 2008

571 pages

Select type: E-Book



With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research.

Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively.

This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.
Natural Peptide Libraries of Microbial and Mammalian Origin
Polymer Supported Organic Synthesis: A Review
From Multiple Peptide Synthesis to Peptide Libraries
Chemical Synthesis of Peptide Libraries
The Versatility of Nonsupport-Bound Combinatorial Libraries
Combinatorial Library Based on the One-Bead-One-Compound Concept
Peptide and Cyclopeptide Libraries: Automated Synthesis, Analysis, and Receptor Binding Assays
Mass Spectrometric Analysis of Peptide Libraries
Multiple Sequence Analysis of Natural and Synthetic Peptide Libraries
Epitope Mapping with the Use of Peptide Libraries
Cyclic Peptide Libraries: Recent Developments
Random Peptide Libraries as Tools in Basic and Applied Immunology
Combinatorial Synthesis on Membrane Supports by the SPOT-Technique: Imaging Peptide Sequence and Shape Space
Automated Synthesis of Nonnatural Oligomer Libraries: The Peptoid Concept
Synthesis and Evaluation of Three 1,4-Benzodiazepine Libraries
PEG Grafted Polystyrene Tentacle Polymers: Physico-Chemical Properties and Applications in Chemical Synthesis
Supports for Solid-Phase Organic Synthesis
QMass: A Computer Program for the Analysis of Mass Spectra of Peptide Libraries