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Cycloaddition Reactions in Organic Synthesis

Cycloaddition Reactions in Organic Synthesis

Shu Kobayashi (Editor), Karl Anker Jorgensen (Editor)

ISBN: 978-3-527-60025-0 December 2001 344 Pages


Cycloaddition reactions are among the most important tools for synthesis in organic chemistry, since these reactions are vital to the modern synthesis of natural products and biologically active substances.

Metal catalysis plays an increasingly important role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecules. Kobayashi and Jorgensen's handbook provides numerous examples of metal-catalyzed reactions, including [2+1], [3+2] and [4+2] cycloadditions. Important reactions such as carbo- and hetero-Diels-Alder, carbocyclic, cyclopropanation and 1,3-dipolar cycloaddition reactions are discussed. A large number of experimental procedures gives a concrete idea of the use of metal-catalyzed cycloaddition reactions in modern synthesis.

The book is aimed at chemists in industry or academia, who want to effectively use cycloadditions in their work.
Catalytic Asymmetric Diels-Alder Reactions
Recent Advances in Palladium-catalyzed Cycloadditions Involving Trimethylenemethane and its Analogs
Enantioselective [2+1] Cycloaddition: Cyclopropanation with Zinc Carbenoids
Catalytic Enantioselective Cycloaddition Reactions of Carbonyl Compounds
Catalytic Enantioselective Aza Diels-Alder Reactions
Asymmetric Metal-catalyzed 1,3-Dipolar Cycloaddition Reactions
Aqua Complex Lewis Acid Catalysts for Asymmetric 3+2 Cycloaddition Reactions
Theoretical Calculations of Metal-catalyzed Cycloaddition Reactions
"...highly useful coverage of these rapidly expanding research areas..." (Synthesis, No.10, 2002)

"...surveys the various types of meal-catalyzed cycloaddition reactions and their applications in organic synthesis." (SciTech Book News, Vol. 26, No. 2, June 2002)

" contains a number of excellent current reciews of the subject..." (Chemistry & Industry, 4 November 2002)

"...excellent book...will be appreciated by chemists in academia and industry..." (Journal of Natural Products, 2003)