Skip to main content

DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy

DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy

Martin Schleef (Editor)

ISBN: 978-3-527-60753-2

May 2006, Wiley-Blackwell

275 pages

Description

With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.
As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.
Preface
DNA Vaccines: an Overview
DNA as a Pharmaceutical: Regulatory Aspects
From Bulk to Delivery: Plasmid Manufacturing and Delivery
Minimized, CpG-Depleted and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy
Localized Nucleic Acid Delivery: a Discussion of Selected Methods
DNA Needle Injection
Needleless Jet Injection of Naked DNA von Nonviral in vivo Gene Transfer
Plasmid Inhalation: Delivery to the Airways
Hydrodynamic Gene Delivery
DNA Pharmaceuticals for Skin Diseases
Electrotransfection: an Overview
Electrogenetransfer in Clinical Applications
Cancer Inhibition in Mice after Systematic Application of Plasmid Driven Expression of Small Interfering RNAs
Index
"It makes a valuable contribution to an important, topical and rapidly growing area of research and will be useful and of interest to students and professors, specialists and beginners in the field. I recommend it strongly, to libraries and individual researchers, in areas ranging all the way from biological chemistry to medicine." ChemMedChem