- This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).
- Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials.
- The book integrates information from human and animal studies.
- The book considers T1D within the broader context of autoimmune disease.
- The format contains several discussions, which address specific questions and provides guidelines for future strategies and solutions for discovering a cure.
Introduction: whither gene–environment interactions?
2. Rudolf Uher
Gene–environment interaction: overcoming methodological challenges
3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D’Amato
Gene–environment interaction and behavioural disorders: a developmental perspective based on endophenotypes
4. Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin
Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman
Role of gene–stress interactions in gene-finding studies
6. Kenneth A. Dodge
Practice and public policy in the era of gene–environment interactions
7. Kristi B. Adamo and Frédérique Tesson
Gene–environment interaction and the metabolic syndrome
General discussion II
8. Stephen P. Robertson and Richie Poulton
Longitudinal studies of gene–environment interaction in common diseases—good value for money?
9. Kee-Seng Chia
Gene–environment interactions in breast cancer
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches to understanding how gene–environment interactions work to predict susceptibility and outcomes of infections
11. Steven R. Kleeberger and Hye-Youn Cho
Gene–environment interactions in environmental lung diseases
General discussion III
12. Fernando D. Martinez
Gene–environment interaction in complex diseases: asthma as an illustrative case
13. Michael Rutter
Conclusions: taking stock and looking ahead
Index of contributors