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Dose-Response Analysis for Risk Assessment

Dose-Response Analysis for Risk Assessment

Miyoung Yoon, Harvey J. Clewell III, P. Robinan Gentry, Melvin E. Andersen

ISBN: 978-1-119-09746-4

Jun 2020

496 pages

Select type: Hardcover

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Description

Uniquely dedicated to the topic of dose-response analysis, this book reviews fundamental concepts and guides readers to understand advancing methods and practices that include biological and computational technologies.

•    Aids the interpretation of in vitro and in vivo data for chemical dose-response relationships, helping risk assessors derive acceptable or reference toxicity values
•    Addresses challenges in characterizing both dose and response in a dose-response analysis
•    Brings together otherwise-scattered information and examples into one place for training and reference
•    Includes coverage of cancer, epidemiological data, physiologically-based pharmacokinetic (PBPK) and biologically-based dose-response (BBDR) modeling, data collection, cellular network modeling, toxicity threshold, and gene expression