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Drug Delivery in Oncology: From Basic Research to Cancer Therapy, 3 Volume Set

Drug Delivery in Oncology: From Basic Research to Cancer Therapy, 3 Volume Set

Felix Kratz (Editor), Peter Senter (Editor), Henning Steinhagen (Editor)

ISBN: 978-3-527-64775-0

Sep 2013

1822 pages

$512.99

Description

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field.

The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field.

By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Volume 1:
PRINCIPLES OF TUMOR TARGETING
Limits of Conventional Cancer Chemotherapy
Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery
Enhanced Permeability and Retention Effect in Relation to Tumor Targeting
Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design
Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates
Antibody-Directed Enzyme Prodrug Therapy (ADEPT) -
Basic Principles and its Practice So Far

TUMOR IMAGING
Imaging Techniques in Drug Development and Clinical Practice
Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery
Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT

Volume 2:
MACROMOLECULAR DRUG DELIVERY SYSTEMS
Antibody-Based Systems
Empowered Antibodies for Cancer Therapy
Mapping Accessible Vascular Targeting to Penetrate Organs and Solid Tumors
Considerations of Linker Technologies
Antibody-Maytansinoid Conjugates: From the Bench to the Clinic
Calicheamicin Antibody-Drug Conjugates and Beyond
Antibodies for the Delivery of Radionuclides
Bispecific Antibodies and Immune Therapy Targeting

POLYMER-BASED SYSTEMS
Design of Polymer-Drug Conjugates
Dendritic Polymers in Oncology: Facts, Features, and Applications
Site-Specific Prodrug Activation and the Concept of Self-Immolation
Ligand-Assisted Vascular Targeting of Polymer Therapeutics
Drug Conjugates with Poly(Ethylene)Glycole
Thermo-Responsive Polymers
Polysaccharide-Based Drug Conjugates for Tumor Targeting
Serum Proteins as Drug Carriers of Anticancer Agents
Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer
Clinical Experience with Drug-Polymer Conjugates

NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS -
LIPID-BASED SYSTEMS
Overview on Nanocarriers as Delivery Systems
Development of PEGylated Liposomes
Immunoliposomes
Responsive Liposomes (for Solid Tumor Therapy)
Nanoscale Delivery Systems for Combination Chemotherapy

NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS -
POLYMER-BASED SYSTEMS
Micellar Strcutures as Drug Delivery Systems
Tailor-Made Hydrogels for Tumor Delivery
pH-Triggered Micelles for Tumor Delivery
Albumin-Drug Nanoparticles
Carbon Nanotubes

Volume 3:
LIGAND-BASED DRUG DELIVERY SYSTEMS
Cell-Penetrating Peptides in Cancer Targeting
Targeting to Peptide Receptors
Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy
Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors
Drug Conjugates with Polyunsaturated Fatty Acids

SPECIAL TOPICS
RNA Drug Delivery Approaches
Local Gene Delivery for Therapy of Solid Tumors
Viral Vectors for RNA Interference Applications in Cancer Research and Therapy
Design of Targeted Protein Toxins
Drug Targeting to the Central Nervous System
Liver Tumor Targeting
Photodynamic Therapy: Photosensitizers Targeting and Delivery
Tumor-Targeting Strategies with Anticancer Platinum Complexes

“The book is easy to follow, and the majority of chapters have an updated bibliography. Furthermore, most of them contain diagrams and figures that allow the topic to be easily followed. In short, it is a book where actual issues regarding the use of controlled drug-delivery systems in pathology like cancer are described in a detailed way.”  (ChemMedChem, 1 October 2012)