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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

Drug Selectivity: An Evolving Concept in Medicinal Chemistry

Norbert Handler (Editor), Helmut Buschmann (Series Editor), Raimund Mannhold (Series Editor), Jörg Holenz (Series Editor)

ISBN: 978-3-527-67441-1

Nov 2017

536 pages

$184.99

Description

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process.
The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
PART I. INTRODUCTION
Polypharmacology in Drug Discovery

PART II. SELECTIVITY OF MARKTETED DRUGS
Kinase Inhibitors
New Indications for Marketed Drugs
Discovery Technologies of New Indications

PART III. FIXED-DOSE COMBINATIONS
The Growing Market of Fixed-Dose Combinations

PART IV. UNSELECTIVE DRUGS IN DRUG DISCOVERY
The Growing Importance of Individualising Drugs
Drug Discovery Strategies for the Generation of Multi-Target Ligands against Neglected Tropical Diseases
Designing-In Approach
The Linker Approach (Drug-Conjugates)
Merged Multiple Ligands
Pharmacophore Generation of Multiple Ligands
Cellular Assays

PART V. THERAPEUTIC AREAS FOR DESIGNED MULTIPLE LIGANDS
5HT Transporter-Based Multiple Ligands for Depression
Multiple Ligands Targeting the Angiotensin System for Hypertension
PPAR-Based Multiple Ligands for Metabolic Disease
Antibiotics
Multiple Ligands in Cancer Therapy
Multiple Ligands in Neurodegenerative Diseases