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Drug Targeting: Organ-Specific Strategies

Drug Targeting: Organ-Specific Strategies

Grietje Molema (Editor), Dirk K. F. Meijer (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Hendrik Timmerman (Series Editor)

ISBN: 978-3-527-60006-9

Oct 2001

416 pages

Select type: O-Book

Description

How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is ""Drug Targeting"".
This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.
Preface
Foreword
Drug Targeting: Basic Concepts and Novel Advances
Brain Specific Drug Targeting Strategies
Pulmonary Drug Delivery: Delivery to and Through the Lung
Cell Specific Delivery of Anti-Inflammatory Drugs to Hepatic Endothelial and Kupffer Cells for the Treatment of Inflammatory Liver Diseases
Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tubular Cell of the Kidney Using Macromolecular and Pro-Drug Approaches
A Practical Approach in the Design of Colon Specific Drug Delivery Systems
Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs
Strategies for Specific Drug Targeting to Tumour Cells
Tumour Vasculature Targeting
Phage Display Technology for Target Discovery in Drug Delivery Research
Development of Proteinaceous Drug Targeting Constructs Using Chemical and Recombinant DNA Approaches
Use of Human Tissue Slices in Drug Targeting Research
Pharmacokinetic/Pharmacodynamic Modelling in Drug Targeting
Drug Targeting Strategy: Scrutinize the Concepts before Screening the Constructs
""there have been few books that set out to give an overview of the state of the art in the field. This excellent text fills that gap and is a must for the bookshelves of academic and industrial research scientists...The book is excellent and well researched. ... A welcome addition to the library!"" Angewandte Chemie International Edition Vol. 41, No. 7 April 2002