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Effects of Genome Structure and Sequence on the Generation of Variation and Evolution, Volume 1267

Effects of Genome Structure and Sequence on the Generation of Variation and Evolution, Volume 1267

Lynn H. Caporale (Editor)

ISBN: 978-1-573-31887-7

Oct 2012, Wiley-Blackwell

252 pages

Select type: Paperback

In Stock



The structure of DNA varies along its sequence, which can lead to sequence-dependent variations in the fidelity of DNA copying and repair. And because the probability of distinct classes of mutations varies along a DNA sequence, variation that affects fitness will have evolutionary implications, as selection acts on heritable variation.

This Annals volume brings together a broad interdisciplinary group of researchers to explore the impact of increasing understanding of DNA structure, repair, replication, and organization on interrelated subjects ranging from evolution, to dependence of the effect of mutagens on environmental and sequence context, to noncanonical forms of information representation in genomes.

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Overview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution 1.
Lynn Helena Caporale

Genome hyperevolution and the success of a parasite 11.
J. David Barry, James P. J. Hall, and Lindsey Plenderleith

The tricky path to recombining X and Y chromosomes in meiosis 18.
Liisa Kauppi, Maria Jasin, and Scott Keeney

Sites of genetic instability in mitosis and cancer 24.
Anne M. Casper, Danielle M. Rosen, and Kaveri D. Rajula

The genome: an isochore ensemble and it’s evolution  31.
Giorgio Bernardi

Multiple levels of meaning in DNA sequences, and one more 35.
Edward N. Trifonov, Zeev Volkovich, and Zakharia M. Frenkel

Evolution of simple sequence repeat-mediated phase variation in bacterial genomes 39.
Christopher D. Bayliss and Michael E. Palmer

Indirect selection of implicit mutation protocols 45.
David G. King

G4 motifs in human genes 53.
Nancy Maizels

Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes 61.
Baldomero M. Olivera, Maren Watkins, Pradip Bandyopadhyay, Julita S. Imperial, Edgar P. Heimer de la Cotera, Manual B. Aguilar, Estuardo Lopez Vera, Gisela P. Concepcion, and Arturo Lluisma

Integrons and gene cassettes: hotspots of diversity in bacterial genomes 71.
Ruth M. Hall

Creative deaminases, self-inflicted damage, and genome evolution 79.
Silvestro G. Conticello

Three-dimensional architecture of the IgH locus facilitates class switch recombination 86.
Amy L. Kenter, Scott Feldman, Robert Wuerffel, Ikbel Achour, Lili Wang, and Satyendra Kumar

Preaching about the converted: how meiotic gene conversion influences genomic diversity 95.
Francesca Cole, Scott Keeney, and Maria Jasin

Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli 103.
J.M. Moore, Hallie Wimberly, P.C. Thorton, Susan M. Rosenberg, and P.J. Hastings

Implications of genetic heterogeneity in cancer 110.
Michael W. Schmitt, Marc J. Prindle, and Lawrence A. Loeb

Corrigendum for Ann. N.Y. Acad. Sci. 2009. 1182: 47-57 117.