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Enantiocontrolled Synthesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets

Enantiocontrolled Synthesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets

Vadim A. Soloshonok (Editor)

ISBN: 978-0-471-97372-0 July 1999 690 Pages

 Hardcover

Out of stock

$895.00

Description

Written by a leading expert in the field, this is a comprehensivereview of the methods for preparing stereochemically definedfluorine-containing compounds of biomedical importance.

Fluorinated organic compounds are well known for their unusualreactivity but the growing importance of these compounds in thebiomedical field has been accompanied by an increasing awareness ofthe necessity to synthesise and explore the biological propertiesof stereochemically defined fluoro-compounds. This is the firstbook written on this exciting area of research.

It contains:

* detailed reviews on stereocontrolled synthesis of biologicallyimportant compounds

* 21 chapters covering the main areas of asymmetric synthesis andbiocatalysts where fluorine plays a key role

* mechanisms and methods for synthesizing fluoro-organiccompounds

Written for professionals involved in organic, physical andorganofluorine chemistry, natural product synthesis, biological,pharmaceutical and other life science related industries.
1. Asymmetric Fluorination

2. Asymmetric of Fluoroalkylation

3. Synthesis of Stereochemically Defined Fluoro-Organic Compoundsvi Dehydroxy-Fluorination and Related Reactions

4. Asymmetric Synthesis of Fluoro-Organic Compounds via ChiralSulfoxide Chemistry

5. Synthesis of Stereochemically Defined Trifluoromethyl-ContainingCompounds from (S)-3,3,3-Trifluoropropene Oxide

6. Asymmetric Reduction of Fluorine-Containing CarbonylCompounds

7. Asymmetric Aldol Reactions of Fluoro-Carbonyl Compounds

8. Asymmetric Michael Addition of Reactions of Fluorocarbons

9. Asymmetric Oxidation of Fluoro-Olefins

10. Biocatalytic Approach to Enantiomerically EnrichedFluoro-Organic Compounds

11. Stereocontrolled Syntheses of Fluorinated Carbohydrates

12. Asymmetric Synthesis of Fluoro-amino acids

13. Chiral non-racemic Fluorinated Nucleosides -
Recent Synthetic Methods

14. Asymmetric Syntheses and Resolutions of Fluorinated VolatileAnesthetics

15. Fluorine-Containing Chiral Auxiliaries and Ligands for GeneralAsymmetric Synthesis

16. Fluorine-Containing Agents for Determining Enantiomeric Excessof Chiral Molecules

17. Fluorine-Containing Chiral Liquid Crystals: Syntheses andProperties

18. Synthesis of Enantiopure alpha-Trifluoromethyl Alcohols viaChiral Lewis Acid-Catalyzed Carbonyl-Ene Reactions and theirApplication in the Design of New Liquid Crystals

19. Coordination Ability of Fluorine to Proton or Metals Based onExperimental and Theoretical Evidence

20. Physical and Structural Size of Fluorine in Fluoro-OrganicCompounds

21. The Chemical and Physiological Size of Fluorine
"It is clearly the view of the editor and authors who have contributed to this volume that organofluorine chemistry is at a new threshold with an array of methods now available to place fluorine and fluorinated functional groups at stereogenic centres. Such compounds have hardly been exploited commercially. The wealth of information in this book demonstrates this focus which one anticipates will have an increasing impact on the fine chemical, pharmaceuticals and agrochemicals sectors. The book is packed with examples from the recent literature and the readers' attention is continually drawn to points of detail and anecdotes as the volume is browsed. This is not just a book for specialists in organo-fluorine chemistry, it is a book for all organic chemists. ... This is a splendid book.", (David O'Hagan, Natural Products Reports)