Skip to main content

Encyclopedia of Drug Metabolism and Interactions, Volume 2, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

Encyclopedia of Drug Metabolism and Interactions, Volume 2, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

Alexander V. Lyubimov

ISBN: 978-1-118-14974-4

Nov 2012

600 pages

Select type: Hardcover

$283.99

Product not available for purchase

Description

The ideal place to begin researching any question involving drug metabolism and interactions

The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction within the human body. This six-volume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written and edited by leading international experts in the field.

By collecting and reviewing the current literature in the field in one expertly organized work, this encyclopedia is the ideal place to begin researching any question involving drug metabolism and interactions. Readers will find such important topics and working tools as:

  • Inhibited or induced enzymes and their impact on drug toxicity and altered response in both animal and human models
  • Effects of both genetic and non-genetic factors on drug metabolism
  • Relationships between a drug metabolism, its activation or inactivation, and a drug's potential toxicity/safety
  • Examples demonstrating all aspects of drug metabolism and interactions in silico, in vitro, in laboratory animals, and in humans
  • Methods and protocols enabling readers to perform seamless studies of metabolism and drug interactions

All articles are based on recent findings and standards of practice. By reviewing and contextualizing the current literature, the authors offer new perspectives on our current state of knowledge as well as future directions for research in drug metabolism and interactions. References at the end of each article serve as a gateway to the literature.

The Encyclopedia of Drug Metabolism and Interactions is recommended for researchers, physicians, and students at all levels. It introduces the basics to novices and explores the latest science and applications for more experienced investigators.

Encyclopedia of Drug Metabolism and Interactions

This item: Encyclopedia of Drug Metabolism and Interactions, Volume 2, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

Encyclopedia of Drug Metabolism and Interactions, Volume 2, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

(Hardcover $283.99)

Purchased Together:$1,965.00

Contributors xi

Preface to the Encyclopedia xxv

Preface—Volume 2 xxix

PART III General Principles of ADME. Drug Transporters and Other Mechanisms of Transport 1

1 ADME Profiling in Drug Discovery and Development: An Overview 3
Tonika Bohnert and Chandra Prakash

2 Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption 45
John M. DeSesso, Catherine F. Jacobson, and Amy Lavin Williams

3 Oral Absorption: from Physiology to Regulatory 81
Fran Berlioz-Seux

4 General Principles of Drug Distribution 107
Gillian C. Wallace, Diane B. Ramsden, and M. Helen Grant

5 ABC Drug Transporters and Their Impact on Drug Disposition/Drug Sensitivity and Resistance 155
Steven J. Wolf and Caroline G. Lee

6 Solute Carrier (SLC) Family Transporters 195
Jasminder Sahi, Yurong Lai, and Caroline Lee

7 Mechanisms of Drug Metabolism 247
Robert S. Foti, Dan A. Rock, Larry C. Wienkers, and Jan L. Wahlstrom

8 Extrahepatic Drug-Metabolizing Enzymes and Their Significance 315
Shalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal, and Saranjit Singh

9 Mass Balance Studies in Animals and Humans 415
Tsuhan Lin, Tycho Heimbach, Rakesh Gollen, and Handan He

10 Bioavailability and Bioequivalence 455
Benny M. Amore

11 Interspecies Pharmacokinetic Scaling and the Prediction of Human Pharmacokinetics Using Animal and Cell Models 495
Meihua Rose Feng, Nan Zheng, Xinyuan Zhang, Yea Min Huh, and Jing-yu Yu

12 The Significance and Determination of Plasma Protein Binding 531
Anagha A. Damre and Krishna R. Iyer

13 Excretion Systems 549
Kazuya Maeda and Yuichi Sugiyama

14 Pharmacokinetics and Toxicokinetics in Drug Discovery and Development 581
Manthena V. S. Varma, Zaher A. Radi, Charles J. Rotter, John Litchfield, and Ayman F. El-Kattan

15 Pharmacokinetic Data Analysis and Modeling of ADME Processes 599
Steven Zhang

16 Physiologically Based Pharmacokinetic (PBPK) Modeling: Usefulness and Applications 637
Han-Joo Maeng, Edwin C. Y. Chow, Jianghong Fan, and K. Sandy Pang

17 Pharmacodynamics 685
Indranil Rao, Vinay HK, and Sandhya Mandlekar

18 Translational Drug Discovery Research: Integration of Medicinal Chemistry, Computational Modeling, Pharmacology, ADME, and Toxicology 737
Subrahmanyam Vangala, Jakir Pinjari, Prashant Patole, Selvan Ravindran, Rajeev Gangal, Pralhad Wangikar, Sudipta Basu, Tausif Ahmed, and Himanshu Rastogi

PART IV ADME of Some Specific Groups of Drugs and Delivery Systems 791

19 ADME of Herbal Dietary Supplements 793
Sheela PaiBir and Sadayappan V. Rahavendran

20 ADME of Anticancer Drugs 841
Hiroshi Yamazaki

21 ADME of Cardiovascular Drugs 855
Hong Liu and Richard Voorman

22 Disposition of Biological Therapeutics: Monoclonal Antibodies, Proteins, and Peptides 895
Dan A. Rock, Larry C. Wienkers, and Marc W. Retter

23 ADME of Natural Toxins 917
Vanessa González-Pérez and David J. Kroll

24 Influence of Changes in Physiology, Transporters, and Enzyme Expression on Disposition and Metabolism of Drugs during Pregnancy and Clinical Implications 933
Shalu Jhajra, Saranjit Singh, Karsten A. Holm, Ali Said Faqi, and Jasminder Sahi

Index 963