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Encyclopedia of Drug Metabolism and Interactions, Volume 5, Bioanalytical Approaches

Encyclopedia of Drug Metabolism and Interactions, Volume 5, Bioanalytical Approaches

Alexander V. Lyubimov (Editor-in-Chief)

ISBN: 978-1-118-14978-2

Nov 2012

600 pages

Select type: Hardcover


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The ideal place to begin researching any question involving drug metabolism and interactions

The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction within the human body. This six-volume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written and edited by leading international experts in the field.

By collecting and reviewing the current literature in the field in one expertly organized work, this encyclopedia is the ideal place to begin researching any question involving drug metabolism and interactions. Readers will find such important topics and working tools as:

  • Inhibited or induced enzymes and their impact on drug toxicity and altered response in both animal and human models
  • Effects of both genetic and non-genetic factors on drug metabolism
  • Relationships between a drug metabolism, its activation or inactivation, and a drug's potential toxicity/safety
  • Examples demonstrating all aspects of drug metabolism and interactions in silico, in vitro, in laboratory animals, and in humans
  • Methods and protocols enabling readers to perform seamless studies of metabolism and drug interactions

All articles are based on recent findings and standards of practice. By reviewing and contextualizing the current literature, the authors offer new perspectives on our current state of knowledge as well as future directions for research in drug metabolism and interactions. References at the end of each article serve as a gateway to the literature.

The Encyclopedia of Drug Metabolism and Interactions is recommended for researchers, physicians, and students at all levels. It introduces the basics to novices and explores the latest science and applications for more experienced investigators.

Encyclopedia of Drug Metabolism and Interactions

This item: Encyclopedia of Drug Metabolism and Interactions, Volume 5, Bioanalytical Approaches

Encyclopedia of Drug Metabolism and Interactions, Volume 2, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs

(Hardcover $283.99)

Purchased Together:$1,965.00

Contributors xi

Preface to the Encyclopedia xxv

Preface—Volume 5 xxix

PART IX Bioanalytical Methods of Studying Metabolism 1

1 Bioanalytical Support for Both In Vitro and In Vivo Assays Across Drug Discovery and Drug Development 3
Walter A. Korfmacher

2 General Principles of Mass Spectrometry: GC-MS, LC-MS, and LC-MS/MS 21
Brian F. Thomas, Richard C. Daw, and Megan Grabenauer

3 Infusion Nanoelectrospray Ionization Mass Spectrometry 47
Jack Henion

4 A Perspective on the Evolving Field of Ambient Ionization Mass Spectrometry 87
Michael S. Bereman

5 Matrix-Assisted Laser Desorption/Ionization 119
Patrick A. Limbach and Mahmud Hossain

6 Triple Quadrupole and Quadrupole Ion Trap Mass Spectrometers 151
Mark E. Ridgeway and Gary L. Glish

7 Hybrid Mass Analyzers in Drug Metabolism Applications 177
Silvi A. Chacko, Ragu Ramanathan, W. Griffith Humphreys, and Jonathan L. Josephs

8 Imaging Mass Spectrometry 215
Alexandra van Remoortere, Emrys A. Jones, Andr´e M. Deelder, and Liam A. McDonnell

9 Gas-Phase Ion Mobility-Mass Spectrometry (IM-MS) and Tandem IM-MS/MS Strategies for Metabolism Studies and Metabolomics 257
Jody C. May, Cody R. Goodwin, and John A. McLean

10 Inductively Coupled Plasma Mass Spectrometry for Analysis of Metal-Containing Pharmaceuticals 287
Bente Gammelgaard, Stefan St¨urup, and Charlotte Møller

11 On-Line Electrochemical/LC-MS Techniques for Profiling and Characterizing Metabolites 313
Paul H. Gamache and Ian N. Acworth

12 Nuclear Magnetic Resonance Spectroscopy for the Study of Drug Metabolism 331
Michael D. Reily, Stella Huang, Janet Caceres-Cortes, Kim Johnson, and Yue-Zhong Shu

13 Whole-Body Autoradiography and Microautoradiography in Drug Discovery and Development 361
Eric G. Solon

14 Ligand-Binding Assays 395
Thorsten Verch and Ray Bakhtiar

15 Micellar Electrokinetic Chromatography 421
Morteza G. Khaledi

16 Direct Biofluid Analysis Systems 445
Ian A. Blair

17 Analytical Method Development and Validation in Accordance to the Regulatory Guidelines 469
Steve E. Unger

18 Leveraging Advances in HPLC and Sample Preparation to Maximize DMPK Data Quality 515
Roger N. Hayes

19 High Throughput Quantitative Mass Spectrometry 545
Jon D. Williams and Russell Grant

20 The Role of Biomarkers in Drug Discovery and Development: Enabling PK/PD 577
Gabriella Szekely-Klepser and Erick Kindt

21 Bioanalytics for Human Microdosing 599
Bruce A. Buchholz, Miranda J. Sarachine Falso, Benjamin J. Stewart, Kurt W. Haack, Ted J. Ognibene, Graham Bench, Gary A. Salazar Quintero, Michael A. Malfatti, Kristen S. Kulp, and Kenneth W. Turteltaub

22 Bioactivation and Reactive Metabolite Assays 627
Wei Tang and Zhoupeng Zhang

23 Plasma Protein Binding Methods in Drug Discovery and Development: Bioanalysis 657
Lucinda H. Cohen and Deborah A. Nicoll-Griffith

Index 675