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Endocrine Facets of Ageing

Derek J. Chadwick (Editor), Jamie A. Goode (Editor)

ISBN: 978-0-471-48636-7 February 2002 298 Pages

Description

Social and medical developments have recently led to a dramatic increase in life expectancy. This has inspired the study of organismic changes associated with healthy ageing, in particular the erosion of homeostatic capabilities in multiple endocrine systems.

This book reviews advances in the understanding of endocrine facets of ageing. It considers the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal, addressing the influence of external factors on the rates of progression of endocrine sequelae in ageing, the mechanisms that underlie the disarray of endocrine axes in ageing, and the implications of therapeutic reconstitution of hormones in ageing.

This book:

  • Considers the mechanisms of ageing and hormonal changes that occur with age.
  • Discusses healthy ageing and the relationships between hormonal changes and pathophysiological conditions such as atherosclerosis and age-related bone loss.
  • Draws together contributions from basic and clinical research, to identify and stimulate promising new research directions.
Chair's Introduction (J.D. Veldhuis)

Endocrine aspects of healthy ageing in men(A.W. van den Beld andS.W.J. Lamberts)

Ageing, stress and the brain (B.J. Carroll)

Alterations in the ageing corticotropic stress-response axis (P.Bjorntorp)

Male reproductive ageing: using the Brown Norway rat as a model forman (C. Wang et al)

Male reproductive ageing: human fertility, androgens and hormonedependent disease (D.J. Handelsman)

Mechanisms of conjoint failure of the somatotropic and gonadal axesin ageing men (J.D. Veldhuis et al)

Effects of growth hormone and insulin-like growth factor 1deficiency on ageing and 1ongevity (Z. Laron)

The role of the insulin-like growth factor 1 and insulin in ageingand atherosclerosis (A. Ruiz-Torres)

The ageing female reproductive axis -1 Henry G. Burger et al)

The ageing female reproductive axis II: ovulatory changes withperimenopause (J. C. Prior)

The thyroid axis in ageing (H Leitolf et al)

Critical illness as a model of hypothalamic ageing (G. Van denBerghe and S.M. Shalet)

Glucose tolerance, glucose utilization and insulin secretion inageing (D.Elahi et al)

Endocrine causes of age-related bone loss and osteoporosis (B.L.Riggs)

Ageing and water homeostasis (D. Robertson et al)

Summing Up (J.D. Veldhuis)
"...This book certainly represents a useful starting point toreview our current knowledge." (The Endocrinologist, July 2002)

"...The book is helpful to understand the recent advances inthis research field..." (Endocrine Journal, June 2002)

"...The Novartis Foundation should be congratulates for editingthe very instructive discussions..." (Jnl of PediatricEndocrinology & Metabolism, Vol.15, No.6, 2002)

"...I would recommend this book for specialists in thefield of endocrinology..." (Gerontology, Vol.49, No.3,2003)

"...The Novartis Foundation should be congratulated for editingthe very instructive discussions." (Journal of Endocrine Genetics,Vol.3, No.2, 2002)