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Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics

Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics

Tomas G. Villa (Editor), Patricia Veiga Crespo (Editor)

ISBN: 978-0-470-57054-8

Dec 2009

272 pages

Description

Presents the latest research and applications for a new, promising approach to fighting infectious diseases

Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications.

The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores:

  • A new approach to controlling infections using Gram-negative bacteria

  • Bacteriophage holins and their membrane-disrupting activity

  • Anti-staphylococcal lytic enzymes

  • Membrane-targeted enzybiotics

  • Design of phage cocktails for therapy from a host-range point of view

  • Novel methods to identify new enzybiotics

  • Genetically modified phages that deliver suicidal genes to target bacteria

The authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature.

As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.

PREFACE.

CONTRIBUTORS.

1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE (Jan Borysowski and Andrzej Górski).

2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS (Patricia Veiga-Crespo and Tomas G. Villa).

3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA (Juan C. Alonso and Marcelo E. Tolmasky).

4 PHYLOGENY OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa).

5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC (Vincent A. Fischetti).

6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANEDISRUPTING ACTIVITY (María Gasset).

7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES (Jan Borysowski and Andrzej Górski).

8 MEMBRANE-TARGETED ENZYBIOTICS (María Gasset).

9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINT OF VIEW (Lawrence D. Goodridge).

10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE (Jonathan E. Schmitz, Raymond Schuch, and Vincent A. Fischetti).

11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIA (Lawrence D. Goodridge).

CONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa).

INDEX.