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Enzyme Systems that Metabolise Drugs and Other Xenobiotics



Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Costas Ioannides

ISBN: 978-0-471-89466-7 December 2001 588 Pages


This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior exposure to other chemicals
* age-dependent expression
* pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
Xenobiotic Metabolism: An Overview (Ionnides)

Cytochrome P450 (Guengerich)

Flavin Monooxygenases (Cashman)

Amine Oxidases and the Metabolism of Xenobiotics (Tipton and Benedetti)

Molybdenum Hydroxylases (Beedham)

Prostaglandin Synthases (Degen et al)

Lipoxygenases (Kulkarni)

UDP-Glucuronosyltranferases (Bock)

Glutathione S-transferases (Sherratt and Hayes)

Sulphotransferases (Glatt)

Arylamine Acetyltransferases (Levy and Weber)

Mammalian Xenobiotic Epoxide Hydrolases (Arand and Oesch)

Methyltransferases (Creveling)

The Amino Acid Conjugations (Steventon and Hutt)

Deconjugating Enzymes;
Sulphatases and Glucuronidases (Kunert-Keil et al)

Nitroreductases and Azoreductases (Zbaida)
"an invaluable reference book" (ISSX Newsletter, Summer 2002)