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Erythropoietin: Blood, Brain and Beyond



Erythropoietin: Blood, Brain and Beyond

Arthur J. Sytkowski

ISBN: 978-3-527-60543-9 March 2006 Wiley-Blackwell 237 Pages


The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system.

Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents.

The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.
1. Introduction and History
2. Developmental Biology of Erythropoiesis and Erythropoietin Production
3. Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia Dependent Genes
4. Physiology and Metabolism of Erythropoietin
5. Biochemistry and Protein Structure
6. Receptor Biology and Signal Transduction
7. Clinical Disorders of Erythropoietin and its Receptor
8. Recombinant Erythropoietin and the Treatment of Anemia
9. Function of Erythropoietin Outside of Hematopoiesis
10. Erythropoietin and Sport
11. The Future of Erythropoietin
"... in einem einzigen Buch den weiten Informationsbereich über die Wirkweise und Anwendung von Erythropoietin komprimiert."