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Evidence-Based Hematology




This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients.

The book is split into two sections: the first examines the methodology underlying evidence based practice, and the second concentrates on the clinical practice of hematology, providing current “best evidence” to guide practice in a series of well-defined clinical situations.

This clinical reference is an invaluable source of evidence-based information distilled into guidance for clinical practice which will be welcomed by practitioners, trainees and associated health professionals.
Part 1 A Guide to the Evidence.

1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research: Holger J. Sch¨unemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt.

2 An Overview of Systematic Reviews: Martin Prins, Arina ten Cate-Hoek, Pieter Leffers.

3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers: Marcello Di Nisio, Harry R. B¨uller, Patrick M. M. Bossuyt.

4 Finding the Evidence in Hematology: K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes.

5 Applying EBM in Clinical Practice: Alessandro Squizzato, Walter Ageno, Davide Imberti.

6 Using Evidence to Guide the Diagnosis of Disease: Lucas M. Bachmann, Holger J. Sch¨unemann.

Part 2 Hemostasis and Thrombosis.

7 Diagnosis of Deep Vein Thrombosis: Lori-Ann Linkins.

8 The Diagnosis of Acute Pulmonary Embolism: Victor F. Tapson.

9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism: Sam Schulman.

10 Long-Term Anticoagulation in Venous Thromboembolism: Clive Kearon.

11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism: Simon J. McRae, John W. Eikelboom.

12 Inferior Vena Cava Interruption: Michael B. Streiff, Christine L. Hann.

13 Management of Venous Thromboembolism in Pregnancy: Wee-Shian Chan.

14 Pediatric Thrombosis: Anthony K. C. Chan, Paul Monagle.

15 Bridging Anticoagulation in PatientsWho Require Temporary Interruption ofWarfarin for Surgery: James D. Douketis, Scott Kaatz.

16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura: Brian Boulmay, Craig S. Kitchens.

17 Diagnosis and Management of Disseminated Intravascular Coagulation: Julia A. M. Anderson.

18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders: Nigel S. Key, Alice D. Ma.

19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists: Miguel A. Escobar.

20 Diagnosis and Management of Heparin-Induced Thrombocytopenia: Theodore E. Warkentin, Andreas Greinacher.

21 Management of Antiphospholipid Antibody Syndrome: Wendy Lim, Mark A. Crowther.

Part 3 Benign Hematologic Disorders.

22 Clinical Questions in Iron Overload: Antonello Pietrangelo, Nicola Magrini.

23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia: Shivani Srivastava, Richard W. Childs.

24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia: Marc S. Zumberg, Marc J. Kahn.

25 Immune Thrombocytopenic Purpura: James N. George, Sara K. Vesely, George R. Buchanan.

26 Neutropenia: David C. Dale.

27 Hypereosinophilia: Primary and Secondary: Florence Roufosse, Michel Goldman, Elie Cogan.

28 Porphyrias: Gagan Sood, Karl E. Anderson.

29 Membrane and Enzyme Abnormalities of the Erythrocyte: Patrick G. Gallagher, Ernest Beutler.

30 Sickle Cell Disease: Richard Lottenberg, Sally C. Davies.

31 Evidence-based Treatment of Thalassemia Major: Issac Odame, Deborah Rund.

Part 4 Malignant Hematologic Disorders.

32 Acute Lymphoblastic Leukemia in Adults: Stephen Couban, Andrea Kew.

33 Acute Myeloid Leukemia in Adults: Remission: Induction Therapy: Cara A. Rosenbaum, Richard A. Larson.

34 Acute Myeloid Leukemia in Adults: Postremission Therapy: Cara A. Rosenbaum, Richard A. Larson.

35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia: Martin S. Tallman, Syed A. Abutalib.

36 Chronic Lymphocytic Leukemia: Bruce D. Cheson.

37 Chronic Myeloid Leukemia: Irwin Walker.

38 Selected Management of Patients with Myelodysplastic Syndromes: John M. Storring, Karen W. L. Yee.

39 Evidence-based Treatment of Burkitt Lymphoma in Adults: John Gerecitano, David J. Straus.

40 Primary Central Nervous System Lymphoma: Tamara Shenkier.

41 Diffuse Large B-cell Lymphoma: Michael Crump.

42 Follicular Lymphoma: Kevin Imrie, Matthew Cheung.

43 Lymphoblastic Lymphoma: Tyler Y. Kang, John W. Sweetenham.

44 Mantle Cell Lymphoma: C. Tom Kouroukis.

45 Management of Patients with Peripheral T-cell Lymphoma: Kerry J. Savage.

46 Selected Management Issues of Patients with Hodgkin Lymphoma: Ralph M. Meyer.

47 Lymphocyte Predominant Hodgkin Lymphoma: Brandon McMahon, Jonathan W. Friedberg.

48 Management of Patients with Essential Thrombocythemia: Guido Finazzi, Giovanni Barosi, Tiziano Barbui.

49 Management of Patients with Polycythemia Vera: Guido Finazzi, Roberto Marchioli, Tiziano Barbui.

50 Evidence-based Review of Therapies in Multiple Myeloma: Michael Sebag, A. Keith Stewart.

51 Management ofWaldenstrom’s Macroglobulinemia: Christine I. Chen.

52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies: Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin Djulbegovic.


"This book is an excellent collection of current best practices in hematology. It should appeal to all who have to deal with everyday challenges in blood diseases." (Journal of Tropical Pediatrics, June 2009)
Comprehensive clinical book on treating hematological conditions

  • Provides recommendations based on real evidence-based methodology

  • Written by leading hematologists with a knowledge of evidence-based medicine

  • A user friendly approach and layout focuses on diagnosis and management

  • An invaluable source of evidence-based information distilled into guidance for clinical practice that will be welcomed by practitioners, trainees and associated health professionals