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David Evered (Editor), Sarah Clark (Editor)

ISBN: 978-0-470-51344-6 September 2007 316 Pages


Filarial parasites affect over 130 million people in tropical and subtropical regions of the world, causing prolonged and debilitating illnesses ranging from lymphatic inflammation and elephantiasis to skin disease and blindness. This wide-ranging book, the outcome of an international symposium, focuses on the host-parasite interaction in lymphatic filariasis and onchocerciasis. Papers examine all aspects of the pathological and immunological consequences of infection as well as diagnosis, treatment, and control of filarial disease.
Partial table of contents:

Epidemiology of Lymphatic Filariasis (J. W. Mak).

Some Unsolved Problems in the Epidemiology of Onchocerciasis (A. Southgate).

Clinical Responses in Human Onchocerciasis: Parasitological and Immunological Implications (C. D. Mackenzie et al.).

Scanning Electron Microscopy of Brugia Malayi (V. Zaman).

Dynamics of the Filarial Surface (R. E. Howells).

Characterization of the Filarial Genome (K-L.

Sim et al.).

Onchocerca Antigens in Protection, Diagnosis and Pathology (M. E. Parkhouse et al.).

Cell Adherence to Microfilariae of Onchocerca Volvulus: A Comparative Study (J. F. Williams et al.).

Regulation of Immune Responses in Lymphatic Filariasis (W. F. Piessens et al.).

Humoral Immune Responses in Human Onchocerciasis: Detection of Serum Antibodies in Early Infections (N. Weiss & M. Karam).

Antibody Responses to Human Lymphatic Filarial Parasites (R. M. Maizels).

Immunodiagnosis of Bancroftian Filariasis (S. Dissanayake & M. M.


The Cat Infected with Brugia Pahangi as a Model of Human Filariasis (D. A. Denham & C. Fletcher).

Primate Model for Onchocerciasis Research (B. M. Greene).

Ocular Lesions in Onchocerciasis.

Antifilarials and their Mode of Action (D. Subrahmanyam).