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Fluorine-containing Amino Acids: Synthesis and Properties

Fluorine-containing Amino Acids: Synthesis and Properties

Valery P. Kukhar (Editor), Vadim A. Soloshonok (Editor)

ISBN: 978-0-471-95203-9

Apr 1995

422 pages

Select type: Hardcover

In Stock

$970.00

Description

In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids:
* is the first volume devoted to the synthesis and properties of fluorine-containing amino acids
* pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry)
* deals with a rapidly expanding field of research
* has been written by experienced researchers who are responsible for many developments in the field
* highlights the interdisciplinary nature of this topic
Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.
Partial table of contents:

Syntheses of Fluorine-Containing Amino Acids by Methods of Classical Amino Acid Chemistry (V. Tolman).

Preparation of Fluorine-Containing Amino Acids by Methods of Organofluorine Chemistry (V. Kukhar).

Synthesis of Fluorine-Containing Amino Acids by Means of Homogeneous Catalysis (I. Ojima & Q. Dong).

Synthesis of beta-Fluorine-Containing Amino Acids (N. Sewald & K. Burger).

Asymmetric Synthesis of Fluorine-Containing Amino Acids (V. Kukhar, et.

al).

Enzymatic Synthesis of Fluorine-Containing Amino Acids (Y. Matsumura & M. Urushihara).

Enzymatic Resolution of Racemic Fluorine-Containing Amino Acids (T. Miyazawa).

High-Performance Liquid Chromatography of Fluorine-Containing Amino Acids (S. Galushko).

Renin Inhibitors with Fluorine-Containing Amino Acid Derivatives (H. Sham).

Index.