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Focal Therapy in Prostate Cancer

Hashim Uddin Ahmed (Editor), Manit Arya (Editor), Peter R. Carroll (Editor), Mark Emberton (Editor)

ISBN: 978-1-444-34687-9 October 2011 Wiley-Blackwell 200 Pages


This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
Contributor List, vii

Preface, xi

Section I Is there a role for Focal Therapy in Localised Prostate Cancer?, 1

1 The Rationale for Focal Therapy of Prostate Cancer, 3
Cole Davis, Matthew Cooperberg, and Peter R. Carroll

2 Factors That Affect Patients' Choice of Treatment, 11
Deb Feldman-Stewart and Michael D. Brundage

3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17
Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik

4 Selection Criteria for Prostate Cancer Focal Therapy, 29
Rajat K. Jain, Timothy K. Ito, and Samir S. Taneja

Section II How can we accurately locate cancer within the gland?, 37

5 Localisation of Cancer within the Gland: Biopsy Strategies, 39
Winston E Barzell and Rodrigo Pinochet

6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47
Ulrich Scheipers

7 Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, 55
Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers

8 Localization of Cancer within the Gland: Diffusion-Weighted Magnetic Resonance Imaging of the Prostate, 66
Sophie F Riches, Nina Tunariu, and Nandita M deSouza

9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75
Michael S. Gee and Mukesh G. Harisinghani

Section III How can we create discrete tissue necrosis?, 85

10 Energies for Focal Ablation: Cryoablation, 87
John F. Ward

11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98
Katsuto Shinohara

12 High-Intensity Focused Ultrasound, 106
Hashim Uddin Ahmed and Mark Emberton

13 Energies for Focal Ablation: Photodynamic Therapy, 114
Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton

14 Focal Therapy for Prostate Cancer Using Radiation, 126
Irving Kaplan, Elizabeth Genega and Neil Rofsky

15 Image Registration and Fusion for Image-Guided Focal Ablation, 132
Dean Barratt and David Hawkes

Section IV How can we determine the success of Focal Therapy? , 143

16 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145
Al Barqawi, Paul Maroni, and David Crawford

17 Determining Success of Focal Therapy: Imaging, 153
Alex Kirkham and Clare Allen

18 Evaluating Focal Therapy: Future Perspectives, 170
Hashim Uddin Ahmed and Mark Emberton

Index, 179

Colour plate section can be found facing page 116

“Whilst the book is not designed to represent a daily reference guide for the majority of the urological fraternity, it clearly does what it sets out to do; provide an up-to-date and comprehensive analysis of a treatment option that perhaps one day we will routinely consider alongside active surveillance and robotic surgery.”  (Urology News, 1 November 2012)