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Freeze-Drying

Freeze-Drying

Georg-Wilhelm Oetjen

ISBN: 978-3-527-61408-0

Dec 2007

286 pages

Select type: O-Book

Description

Many modern medicines, for example blood derivatives, vaccines, cytostatic drugs, and antibiotics, but also soluble coffee, have one thing in common: freeze-drying is the best method of transforming the perishable substances into a form that keeps well and allows the substances to be stored before being returned almost to their natural state.

This book describes the rules of freeze-drying. The critical process data is not just presented theoretically but explained with regard to practical examples. Application of freeze-drying processes is the main emphasis of this book. Many years of experience in the freeze-drying business allow the author to present valuable criteria for the selection of laboratory or industrial plants. Evaluation of the latest publications guarantees state-of-the-art coverage of information.


Even modern topics, e.g., validation of processes or estimation of acceptable variances from preset values, are taken into account. These valuable tips make the book indispensable for everybody working in the freeze-drying business.
FUNDAMENTALS OF FREEZE-DRYING TECHNOLOGY
Freezing
Drying
Storing
PLANT TECHNOLOGY
Plants for freezing
Components of a freeze-drying plant
Plants for batches up to 10 kg
Large scale plant
Food production plant
PHARMACEUTICAL, BIOLOGICAL, AND MEDICAL PRODUCTS
Proteins and hormones
Viruses; serums, bacteria, yeasts
Antibiotics
Liposomes and nanoparticles
Transplants
FOOD
Vegetables, fruits, and fruit juice
Coffee
Eggs and rice
POWDER OF METAL OXIDE CERAMIC
POINTS OF GENERAL INTEREST
Norms and abbreviations
Validation of processes and plant