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From Genome to Proteome: Advances in the Practice and Application of Proteomics

From Genome to Proteome: Advances in the Practice and Application of Proteomics

Michael J. Dunn (Editor)

ISBN: 978-3-527-61348-9 December 2007 Wiley-Blackwell 552 Pages


As research on the human, animal, plant and microbial genomes matures towards descriptive fullness, the need for understanding the proteome has clearly emerged as the next major endeavor of life sciences. Proteomics - the quantitative analysis of all proteins working in a cell at a specific time and at specific conditions - provides deep insight into the highly organized network of expression, modification and degradation of proteins.
Compiled in this book are reviews and research articles which describe the recent advances and perspectives of this new field of research. The articles are grouped into the following sections:
- Sample Preparation and Solubilization
- Developments in Electrophoresis
- Detection and Quantitation
- Mass Spectrometry
- Proteome Data Analysis and Management
- Prokayotes and Yeast
- Biological Fluids
- Eukaryotic Cells and Tissue
- Oncology
- Plants
Proteomics is a new key for the functional analysis of living systems and of equal importance for basic as well as application oriented research.
Proteome analysis: A pathway to the functional analysis of proteins
Proteomics in human disease: Cancer, heart and infectious disease
Proteomics for genetic and physiological studies in plants
Diagnosis of cellular states of microbial organisms using proteomics
Candida albicans pathogenicity: A proteomic perspective
Genotypes and phenotypes
Replication-induced protein synthesis and its importance to proteomics
Advances in protein solubilization for two-dimensionional electrophoresis
Proteomics and automation
Genomes and proteomes: Towards a multidimensional view of biology
Sample preparation and solubilization
Developments in electrophoresis
Detection and quantitation
Mass spectrometry
Proteome data analysis and management
Prokaryotes and yeast
Biological fluids
Eukaryotic cells and tissue
"...69 articles explain recent developments in proteomics..." (SciTech Book News, Vol. 25, No. 4, December 2001)

"...provides expert practitioners a comprehensive view on advances in the rapidly evolving area of proteomics." (Journal of Proteome Research, Vol. 1, No. 2, March/April 2002)