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Functions of the Proteoglycans

Functions of the Proteoglycans

David Evered (Editor), Julie Whelan (Editor)

ISBN: 978-0-470-51338-5 September 2007 310 Pages


Presents a comprehensive review of current proteoglycan research, which is providing fresh insights into many major chronic diseases. The proteoglycans are a family of macromolecules which contain one or more glycosaminoglycan chains covalently bound to a core protein. Proteoglycans are a major component of the extracellular matrix of connective tissues and help to determine its volume, resiliency, and organization. They are an important medium through which nutrients, hormones, and other solutes are transported to cells, and they play a significant role in cell-cell interactions. Disturbances in proteoglycans occur in rheumatic and connective tissue disorders, degenerative bone disease, vascular disease, renal disease, and malignant disorders.
Partial table of contents:

The Properties and Turnover of Hyaluronan (T. C. Laurent & J. R.



Cartilage Proteoglycans (T. E. Hardingham, et al.).

Biological Roles of Dermatan Sulphate Proteoglycans (L. C. Rosenberg, et al.).

Common Structures of the Core Proteins of Interstitial Proteoglycans (D. Heinegard, et al.).

Biosynthesis and Processing of Proteodermatan Sulphate (H. Kresse, et al.).

Proteoglycan-Collagen Interactions (J. E. Scott).

The Functions of the Heparan Sulphate Proteoglycans (L. A. Fransson, et al.).

Functions of Proteoglycans at the Cell Surface (M. Hook, et al.).

Heparan Sulphate Proteoglycan as Mediator of Some Adhesive Responses and Cytoskeletal Reorganization of Cells on Fibronectin Matrices: Independent Versus Cooperative Functions (L. A. Culp, et al.).

Structure and Function of Basement Membrane Proteoglycans (M. Paulsson, et al.).