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Fundamental Medical Mycology

Fundamental Medical Mycology

Errol Reiss, H. Jean Shadomy, G. Marshall Lyon

ISBN: 978-1-118-10177-3 October 2011 Wiley-Blackwell 648 Pages

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Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists,Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in-depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

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Preface xvii

Acknowledgments xix

Part One Introduction to Fundamental Medical Mycology, Laboratory Diagnostic Methods, and Antifungal Therapy

1. Introduction to Fundamental Medical Mycology 3

2. Laboratory Diagnostic Methods in Medical Mycology 31

3A. Antifungal Agents and Therapy 75

3B. Antifungal Susceptibility Tests 107

Part Two Systemic Mycoses Caused by Dimorphic Environmental Molds (Endemic Mycoses)

4. Blastomycosis 125

5. Coccidioidomycosis 141

6. Histoplasmosis 165

7. Paracoccidioidomycosis 187

8. Penicilliosis 201

9. Sporotrichosis 215

10A. Less Frequent Mycoses Caused by Dimorphic Environmental Molds: Adiaspiromycosis 233

10B. Less Frequent Mycoses Caused by Dimorphic Environmental Molds (Endemic Mycoses): Lobomycosis (Jorge Lôbo’s Disease) 241

Part Three Systemic Mycoses Caused by Opportunistic Yeasts and Pneumocystis

11. Candidiasis and Less Common Yeast Genera 251

12. Cryptococcosis 303

13. Pneumocystosis 333

Part Four Systemic Mycoses Caused by Opportunistic Hyaline Molds

14. Aspergillosis 357

15. Fusarium Mycosis 397

16. Pseudallescheria/Scedosporium Mycosis 413

17A. Mucormycosis 431

17B. Entomophthoramycosis Caused by Basidiobolus ranarum 457

17C. Entomophthoramycosis Caused by Conidiobolus Species 467

Part Five Mycoses of Implantation

18. Chromoblastomycosis 479

19. Phaeohyphomycosis 493

20. Eumycetoma (Madura Foot, Maduramycosis) 513

Part Six Dermatophytosis and Dermatomycoses (Superficial Cutaneous Mycoses)

21. Dermatophytosis 527

22. Dermatomycoses 567

22A. Major Nondermatophytic Fungi from Skin and Nails 567

22B. Superficial Mycosis of the Hair Caused by a Nondermatophyte Mold: Black Piedra 569

22C. Superficial Mycoses Caused by Yeasts and Yeast-like Fungi 571

22D. Chrysosporium and Other Nonpathogenic or Opportunistic Fungi Isolated from Skin and Resembling Dermatophytes in Culture 584

Glossary 589

Answer Key 607

Index 611

“The book does a superlative job in addressing recent advances in medical mycology, which include identifying emerging pathogens, new antifungal drugs and strategies for their use; progress in molecular diagnostics; and up-to- date knowledge about host defenses against fungi, especially opportunistic pathogens.” (Emerging Infectious Diseases, August 2012)

"This text provides the first book in almost 10 years for students and clinicians interested in the medical microbiology of fungi. This new book's scope is well balanced between medical and microbiological knowledge of the major fungi pathogenic for humans." (Clinical Laboratory International, 19 December 2011)