DescriptionComprises the proceedings of a symposium held at the Ciba Foundation, London, February 1988. Contains the latest research results on the inverse relationship between cell proliferation and differentiation and the nature of the genes involved. Included are the studies of cell fusion experiments, the introduction of single chromosomes into malignant cells, and the transfection of individual genes. Also reports on the role of certain oncogenes in normal development, lineage commitment, and tumorigenesis.
Epidemiology of Genetically Determined Cancer (A. Knudson).
Reversion of Tumorigenicity in an EBV-Converted Burkitt's Lymphoma Line (G. Klein).
Loss of Genetic Information in Cancer (W. Cavenee, et al.).
Proviral Position Effects: Possible Probes for Genes That Suppress Transcription (J. Wyke, et al.).
Flat Revertants of EJ Human Bladder Carcinoma Cells Show Two Different Mechanisms of Reversion (H. Patterson, et al.).
A Genetic Basis for Tumor Suppression (E. Stanbridge).
Suppression of Genetic Melanoma in the Fish Xiphophorus (M. Schwab).
The Biology of Tumor Suppression (H. Harris).
Cell Differentiation and Tumor Suppression (L. Sachs).
Index of Contributors.