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Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance

Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance

Alexei V. Demchenko (Editor)

ISBN: 978-3-527-62164-4

Mar 2008

524 pages

Description

Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.
GENERAL ASPECTS OF THE GLYCOSIDIC BOND FORMATION
GLYCOSIDE SYNTHESIS FROM ANOMERIC HALIDES
Glycosyl Fluorides
Glycosyl Chlorides, Bromides, and Iodides
GLYCOSIDE SYNTHESIS FROM 1-OXYGEN-SUBSTITUTED GLYCOSYL DONORS
Hemiacetals and O-Acyl/Carbonyl Derivatives
Glycosyl Imidates
Anomeric Transglycosylation
Phosphites, Phosphates, and Other O--P Derivatives
GLYCOSIDE SYNTHESIS FROM 1-SULFUR/SELENIUM-SUBSTITUTED DERIVATIVES
Thioalkyl and Thioaryl Glycosides
Sulfoxides, Sulfimides, and Sulfones
Xanthates, Thioimidates, and Other Thio Derivatives
Selenoglycosides
OTHER METHODS FOR GLYCOSIDE SYNTHESIS
Orthoesters and Related Derivatives
Dehydro and Anhydro Derivatives
Miscellaneous Glycosyl Donors
Indirect and Special Methods
I recommend this monograph to all those who deal with carbohydrate chemistry or wish to do so. (Angewandte Chemie, July 7, 2008)

"An excellent compilation of chemical glycosylation methods…I read this book with great pleasure…I recommend this monograph to all those who deal with carbohydrate chemistry..." (Angewandte Chemie, 29/2008)