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Handbook of In Vivo Chemistry in Mice: From Lab to Living System

Handbook of In Vivo Chemistry in Mice: From Lab to Living System

Katsunori Tanaka (Editor), Kenward Vong (Editor)

ISBN: 978-3-527-34441-3

Oct 2020

400 pages

$324.99

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Description

This two-volume handbook aims to summarize the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals; the most common animal model being mice. The first volume mainly act as a technical guide, which introduces the reader to general information about live animal experiments and detection methods commonly used for these animals models. The second volume mainly focus on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. By comparing and contrasting currently available chemical and biological techniques, this handbook serves not just as a collection of the pioneering work done in animal-based studies so far, but also as a technical guide to help the reader decide which tools are suitable and best for their experimental needs.
VOLUME 1

(Section I) From Flask to Animals: Challenges and Technical Notes
Chapter 1: Exploring the Biological Milieu of Live Animals
Chapter 2: Summary of Currently Available Mouse Models
Chapter 3: General Notes of Chemical Administration to Live Animals

(Section II) Technical Review of Imaging Methods in Live Animals
Chapter 4: Biocompatible Fluorophores
Chapter 5: Radionuclides for Radiodiagnosis/Radiotherapy
Chapter 6: Invasive Techniques used for Detection in Live Animals
Chapter 7: Fluorescence-based Detection in Live Animals
Chapter 8: Single-photon emission computed tomography (SPECT) Imaging in Live Animals
Chapter 9: Positron emission tomography (PET) Imaging in Live Animals
Chapter 10: Magnetic resonance imaging (MRI) in Live Animals
Chapter 11: Ultrasound Imaging in Live Animals
Chapter 12: Hybrid Imaging Methods in Live Animals
Chapter 13: Current Limitations and Future Prospects for Imaging Methodologies

VOLUME 2

(Section III) Current Techniques of In Vivo Chemistry Performed in Live Animals
Chapter 14: Biocompatible Chemical Reactions
Chapter 15: Ligand-Directed Nucleophilic Substitution Chemistry
Chapter 16: Genetically Encoded Bioorthogonal Protein Tagging
Chapter 17: Bioorthogonal Labeling of Biomolecules
Chapter 18: Bioorthogonal Prodrug Release Strategies
Chapter 19: Transition Metal Catalysis for Bioconjugation Applications
Chapter 20: Transition Metal Catalysts for Therapeutic Applications
Chapter 21: Current Limitations and Future Prospects for In Vivo Chemistry

(Section IV) Selective Targeting Strategies in Live Animals
Chapter 22: Nanoparticle Drug Carriers
Chapter 23: Physical Targeting Methods
Chapter 24: Photoactivatable Targeting Methods
Chapter 25: Monoclonal Antibody Targeting Methods
Chapter 26: Glycan Targeting Methods
Chapter 27: Small Molecules Targeting Methods
Chapter 28: Current Limitations and Future Prospects for Targeting Strategies