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Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition



Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition

Alice D. Ma (Editor), Harold R. Roberts (Editor), Miguel A. Escobar (Editor)

ISBN: 978-1-118-43930-2 October 2012 Wiley-Blackwell 240 Pages

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There is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.

 The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked and discussed throughout.

 New to this edition: coverage of the newer techniques; newer treatment modalities; new oral anticoagulants; update on hemophilia management; more on ITP and greater coverage of new cases as suggested by reviewers.

List of Contributors



General Overview

The hemophilic ankle: an update

The haemophilic knee: An update

Haemophilia with Inhibitors

Inhibitor patient requiring high dose therapy with rVIIa as well as sequential therapy with FEIBA.

Prophylactic therapy in a patient with a high titer inhibitor

Immune Tolerance Induction

Monitoring during ITI

FIX inhibitors

Severe Hemophilia B with high response inhibitor and anaphylactic reaction to factor IX

Inhibitor patient and dental surgery

Haemophilic treatment for procedures

DVT prophylaxis in patients with hemophilia A undergoing orthopedic surgery

Prostate Surgery and Hemophilia

Mild Hemophilia and Intraocular Injections

Endoscopy/colonoscopy and Hemophilia

Dialysis and Hemophilia


PK Studies prior to Orthopedic Surgery

Compartment Syndrome

Successful eradication of factor VIII inhibitor in patient with mild Hemophilia A prior to

hemipelvectomy for extensive hemophilic pseudotumor

Coronary artery disease and hemophilia

Valve Replacement and Hemophilia

Treatment for other conditions

Thyroid biopsy and Hemophilia

Atrial Fibrillation and bleeding disorders

Chronic Upper GI bleeding and hemophilia


Other issues in haemophilia care

Reproductive Options for Hemophilia A Carriers

Mild Hemophilia A with Discrepant FVIII activity levels

Compund Diagnoses

Hemophilia A with tuberous sclerosis and CNS bleed

Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease

Hemophilia A and HHT


Management during procedures

Type I VWD Tonsillectomy

VWD and Dental surgery

VWD and GI surgery

VWD and Obstetric/Gynecologic Procedures

Rare forms of Von Willebrand Disease

Type 2A VWD and recurrent GI bleeding

Type 2B VWD and Thoracic Surgery

Von Willebrand disease 2N


Prothrombin deficiency

Factor V deficiency

Factor VII deficiency

FX deficiency

Factor XI deficiency

Factor XIII deficiency

Combined factor V and factor VIII deficiency 1, 2

Glanzmann Thrombaesthenia

Gardner-Diamond syndrome and VWD

Qualitative Platelet Disorder—QPD


Acquired FVIII inhibitor and B cell neoplasm

FVIII inhibitor and lupus inhibitor

Acquired VWD

A woman with bleeding gums

Bleeding after cardiac surgery

Bleeding in a dialysis patient

A woman with anemia and hematuria

Scalp bleeding in an older gentleman



Heparin induced thrombocytopenia with thrombosis

Heparin Skin Necrosis

Warfarin skin necrosis

Thoracic outlet syndrome 3, 4

Antithrombin Deficiency

May-Thurner syndrome

Thrombosis in a liver transplant patient

Combined thrombophilia


“Overall, this is an extremely well written book suitable for consultants, trainees and, postgraduates, and is a must for all medical college libraries.”  (Indian Journal Medical Research, 1 September 2013)

“This is an important book, as there are not many on the management of hemophilia and hemostasis that use a structured, case-based approach.”  (Doody’s, 26 July 2013)

“On the whole this book is a useful tool for daily practice, particularly for those planning to work outside of a haemophilia comprehensive care centre, where regular exposure to haemophilia is limited.”  (Haem Trainee, 1 April 2013)