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Highlights in Bioorganic Chemistry: Methods and Applications

Highlights in Bioorganic Chemistry: Methods and Applications


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This is a fascinating introduction to the topic. Spanning the spectrum of nucleic acid chemistry, carbohydrates, peptides, molecular recognition, biosynthesis and natural biosynthesis, right up to medical and biophysical chemistry, the book provides advanced students and those already working in the field with a balanced overview.
In more than 30 contributions, a new generation of recognized scientists gives an account of the latest research in such areas as
* Artificial receptors for the stabilization of ß-sheet structures
* Carbohydrate recognition by artificial receptors
* Combinatorial chemistry as a tool for the discovery of catalysts
* The interaction of NO and peroxynitrite with hemoglobin and myoglobin
* Inhibitors against human mast-cell-tryptase as a potential approach to conquering asthma
* The selectivity of DNA replication.
A readily accessible survey for everyone wishing to stay abreast of developments.

With a Foreword by Ronald Breslow.
b-amino acids in Nature: Biosynthesis and Biology
Artificial receptors for the stabilization of b-sheet structures
Conformational equilibria of RNA
Conformational restriction of sphingolipids
Stabilization of peptide-microstructures by coordniation of metal ions
Synthesis and application of proline and piccolic acid derivatives: tools for stabilization of peptide secondary structures.
Artificial rotary motors at the molecular level
Carbohydrate recognition by artificial receptors
Synthetic approaches to study carbohydrate-lectin interactions
Cyclopeptides as macrocyclic host molecules for charged guests
Combinatorial chemistry as a tool for the development of molecular receptors for small peptides
The design of new binding motifs for c-terminal peptides
Modulation of biochemical processes by synthetic hosts for substrates
Interaction of NO and peroxynitrite with hemoglobin and myoglobin
Oxidative splitting of pyrimidine cyclobutane dimers
Inhibitors against human mast-cell-tryptase: a potential approach to attack asthma?
Selectivity of DNA replication
Acridizinium salts and their photophysical interaction with DNA
DNA-detection in homogeneous solution
" the average reader, on reading the contents, a general perspective of the scope of present-day bioorganic chemistry..."
Chemistry and Industry, August 2004

"The book consists of 35 chapters on various aspects of our chemical knowledge of various biological assemblies or of their model counterparts. The chapters have been written by various experts in the field, and I am naturally very stimulated by the state-of-the-art coverage that these colleagues have so nicely given to various aspects in a very professional manner. I have no doubt that the book will be helpful and interesting to both, beginners in the bioorganic research as well as to those who are practitioners in the field as a readily availabele reference book. ... This is a good, affordable reference book with plenty of citations to the review articles and original publications. I strongly recommend this as a reference or handbook to my both young and expert colleagues."
Jyoti Chattopadhyaya, Uppsala University, Sweden, ChemBioChem. 12/2004

"...should be found on the shelves of all chemistry libraries." Journal of the American Chemical Society, January 26, 2004