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Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology

Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology

Bernard Testa, Joachim M. Mayer

ISBN: 978-3-906-39044-4

Nov 2006

800 pages

Select type: Wiley Online Book

Description

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically.
Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Introduction
The Nature and Function of Hydrolytic Enzymes
Classification, Localization and Physiological Roles of Hydrolytic Enzymes
The Hydrolysis of Amides
The Hydrolysis of Lactams
The Hydrolysis of Peptides
The Hydrolysis of Carboxylic Esters
The Hydrolysis of Carboxylic Ester Prodrugs
The Hydrolysis of Esters of Inorganic Acids
Epoxide Hydratase and Epoxide Hydration
Various Reactions of Hydration or Dehydration
Erwähnung in dem Artikel ""Hürdenlauf im Körper"" von Michael Breu auf:

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