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Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond

Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond

Arnold E. Stütz (Editor), H. Paulsen (Foreword by)

ISBN: 978-3-527-60174-5 March 2004 320 Pages


'Nowadays as a result of these manifold synthetic efforts a large number of inhibitors are available, that can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids. The amount of chemical and biochemical information has meanwhile grown to such an extent that it is almost impossible to keep track of the developments. Therefore it is particularly pleasing that contributions from experts for the individual fields are collected together in one work, thus providing a comprehensive overview. In this way this book gives a representative cross-section of the field. The book will be a generally interesting source of information for chemists and biochemists.' (from the foreword by H. Paulsen).

A table which lists over 400 glycosidase inhibitors, more than 200 enzymes with 323 citations and over 1500 invaluable sets of data completes the book.
From the early days of monosaccharides containing nitrogen in the ring
Glycosidase Inhibitors by Basic Sugar Analogs and the Transition State of Enzymic Glycoside Hydrolysis
Taxonomic distribution of iminosugars in plants and their biological activities
Iminosugars as Powerful Glycosidase Inhibitors - Synthetic Approaches from Aldonolactones
Synthetic methods for the Preparation of Iminosugars
potent Glycosidase Inhibitors: Transition State Mimics or Simply Fortuitous binders?
Synthesis and Biological Activity of Castanospermine and Close Analogues
Glycosidase Inhibitors as Useful Tools in Glycobiology and Glycotechnology
Inhibitors of Glycoprotein Processing
Iminosugars: Glycosidase Inhibitors with Nitrogen at the Anomeric Position
Some Reflections on Structure-Activity Relationships in Glycosidas Inhibiting Iminoalditos and Iminosugars
Iminoalditols as Affinity Ligands for the Purification of Glycosidases
Comprehensive Table of Glycosidase Inhibitors and their Properties