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Immunological Tolerance

Immunological Tolerance

Gregory R. Bock (Editor), Jamie A. Goode (Editor)

ISBN: 978-0-470-51553-2

Apr 2008

248 pages

Select type: E-Book



This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Introduction (Mitchison).

Mechanisms of peripheral T cell tolerance (L. Parijs, et al.).

B cell antigen receptor signalling in the balance of tolerance and immunity (Cirnall and FGoodnow).

General discussion I.

The study of self-tolerance using murine haemoglobin as a model self antigen (Williams and Allen).

Tolerance and determinant hierarchy (Schnieder et al).

Molecular genetic studies in lymphocyte apoptosis and human autoimmunity (Martin, et al.).

General discussion II.

A Role for CTLA-4-mediated inhibitory signals in peripheral T Cell tolerance? (Allison, et al).

Antigen-specific CD4+ Tcells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect (pape et al).

Antigen-specific tolerance induction and the immunotherapy of experimental autoimmunity disease (Anderton, et al.).

Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes (Healy, et al.).

Tolerance induction with CD4 monoclonal antibodies (Waldmann et al).

Cross-presentation of self antigens to CD8+ Tcells: the balance between tolerance and autoimmunity (Kurts et al).

General discussion III.

Tolerance induction in mature T lymphocytes (Alferink, et al.).

T lymphocyte-mediated control of autoimmunity (E. Shevach, et al.).

Final General Discussion.