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Innovative Management of Atrial Fibrillation



Innovative Management of Atrial Fibrillation

David Schwartzman (Editor), Marco Zenati (Editor)

ISBN: 978-1-405-17259-2 April 2008 Wiley-Blackwell 208 Pages


Atrial fibrillation is underdiagnosed and preventative strategies are underutilized.

The disease is estimated to rise to an epidemic level, increasing by over 50% by the end of the decade, occurring commonly in the setting of otherwise “healthy” aging.

Innovative Management of Atrial Fibrillation provides a forum for a full discussion on this topical matter. Distinguished experts from both electrophysiology and cardiac surgery place their work in the context of future development, examining the short-comings of current pharmacological treatments. This results in a unique, comprehensive review for cardiologists, cardiac surgeons and anyone who wishes to gain a complete perspective on the fast-paced field of atrial fibrillation.

Material ranges from atrial pathophysiology to advanced minimally invasive surgical ablation and cutting edge palliative and curative therapeutic options. The book also includes the examination of innovative management strategies and the next generation of therapies, giving an essential insight into the emerging potential of gene therapy.

List of Contributors.


Part I. On the Atrial Substrate.

Chapter 1. Electrophysiologic Basis of Atrial Fibrillation.

Chapter 2. Neurological Basis of Atrial Fibrillation.

Chapter 3. Mechanical Basis of Atrial Fibrillation.

Chapter 4. Molecular Basis of Atrial Fibrillation.

Chapter 5. Atrial Plasticity.

Part II. Developing Strategies for AF Management.

Chapter 6. AV Node Ablation.

Chapter 7. Percutaneous Atrial Catheter Ablation.

Chapter 8. Implantable Device Therapy.

Chapter 9. Surgical Ablation Therapy I. Maze Procedure.

Chapter 10. Surgical Ablation Therapy II. Endocardium-Based Catheter Ablation.

Chapter 11. Surgical Ablation Therapy III. Epicardium-Based Catheter Ablation.

Chapter 12. Modification of the Left Atrial Appendage.

Part III. Potential Areas of Opportunity for AF Management.

Chapter 13. Transpericardial Therapy.

Chapter 14. Gene Therapy.

Chapter 15. Tissue Engineering.


"The strength of this book lies in the method it employs in delivering its information. It provides the up-to-date and ongoing research on the topic, beginning with the basic mechanisms involved, and brings it slowly together to the realm of clinical application. It also provides insight to possible future therapies. In doing so, it allows readers to come away feeling that they have developed as strong an understanding of this topic as is currently possible. I would highly recommend this book to anyone with an interest in the treatment of this prevalent disease."  (Sammy Khatib, MD, @Doody's Review Service)
A comprehensive and user-friendly review covering the full spectrum of atrial fibrillation

  • Reviews the shortcomings of current pharmacological treatments, new innovative management strategies (including percutaneous ablation) and examines the next generation of therapies
  • Includes a new highly topical chapter on the emerging potential of gene therapy in atrial fibrillation