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Introduction to Enzyme and Coenzyme Chemistry, 2nd Edition

Introduction to Enzyme and Coenzyme Chemistry, 2nd Edition

T. D. H. Bugg

ISBN: 978-1-444-30536-4 March 2009 Wiley-Blackwell 304 Pages

Description

Enzyme catalysis is a topic of fundamental importance in organic, bio-organic and medicinal chemistry. This new edition of a very popular textbook provides a concise introduction to the underlying principles and mechanisms of enzyme and coenzyme action from a chemical perspective.

Whilst retaining the overall structure of the first edition – preliminary chapters describe the basic principles of enzyme structure and catalysis moving through to detailed discussions of the major classes of enzyme processes in the later chapters – the book has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action. A major feature of the second edition is the inclusion of two-colour figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. Problems, with outline answers, at the end of each chapter give the student the chance to the check their understanding of the material.

As a concise but comprehensive account, Introduction to Enzyme and Coenzyme Chemistry will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry.

Tim Bugg is professor of biological chemistry in the Department of Chemistry, University of Warwick, UK.

Preface; Representation of Protein Three-Dimensional Structures; From jack beans to designer genes; All enzymes are proteins; Enzymes are wonderful catalysts; Methods for studying enzymatic reactions; Hydrolytic and group transfer reactions; Enzymatic redox chemistry; Enzymatic carbon-carbon bond formation; Enzymatic additional/elimanation reactions; Enzymatic transformations of amino acids; Isomerases; Radicals in enzyme catalysis; Non-enzymatic biological catalysis; Appendices; Index
"[T]he well-chosen topics provide a highly readable, coherent introduction to enzyme chemistry."
Journal of Enzyme Inhibition and Medicinal Chemistry<!--end-->

"The first edition of this book was excellent and this new edition consolidates ‘Bugg’ as the pre-eminent textbook on the bioorganic aspects of chemical biology."
Chemistry World

"[T]urns this book into an outstanding choice for those that want to be inside the fabulous world of enzymes."
Physical Science Education Reviews

* Thoroughly updated to present the latest understanding of enzyme catalysis whilst retaining the clarity, depth and structure of the first edition, the book is ideal for students of organic, bio-organic and medicinal chemistry, and chemical biology.

* Completely new chapter on radical mechanisms in enzyme catalysis illustrates the continuing development of our understanding and the excitement of research in this area.

* With highly developed two-colour illustrations, highlighting both reaction mechanism and the interplay between enzyme structure and function that enables such reactions to occur, students can easily grasp the main features of enzyme reactions.

* Problems (with answers) at the end of each chapter help the student to check their understanding of the subject.