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Ischemic Heart Disease

Ischemic Heart Disease

Erling Falk (Editor), Prediman K. Shah (Editor), Pim de Feyter (Editor)

ISBN: 978-1-840-76052-1

May 2007

272 pages

Select type: Hardcover


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A concise straightforward guide to the recognition and management of ischaemic heart disease written by experts from around the world. The text is highly structured and will provide the clinically relevant information needed by today’s practitioners. Firstly the disease is explored covering definition, epidemiology (prevalence, incidence, age and sex) pathogenesis, clinical presentation, diagnostic tests, differential diagnosis, treatment and prognosis. Also described are diagnostic procedures including technique, indications, contraindications, limitations and possible complications. Each topic has been illustrated with high quality colour photographs, line diagrams and radiographs. The book also includes important new information on the use of stem cells in ischaemic heart disease.


1. Burden of Ischemic Heart Disease.

Erling Falk, Prediman K. Shah and Pim J. de Feyter.

2. Anatomy of the Heart.

Coronary arteries.

Saibal Kar.


Saibal Kar and Prediman K. Shah.

Conduction system.

Miguel Valderrábano and C. Thomas Peter.

3. Physiology of the Heart.

Coronary circulation.

Dirk J.G.M. Duncker and Daphne Merkus.

Myocardium and determinants of oxygen demand.

Henry Gewirtz and Ahmed Tawakol.

Conduction system.

Peter Lukac and Anders Kirstein Pedersen.

4. Pathophysiology of Myocardial Ischemia.

Coronary artery anomalies.

Allen J. Taylor and Renu Virmani.

Anerobic myocardial metabolism.

Frans C. Visser.

Collateral development.

Steve Lee, Rajendra Makkar and William Ganz.

Preconditioning, stunning, and hibernation.

Sriram Padmanabhan, Howard Lewin and Prediman K. Shah.

5. Myocardial Ischemia: Compromised Supply.


Jens Flensted Lassen and Erling Falk.

Coronary vasoconstriction and spasm.

Filippo Crea and Gaetano A. Lanza.

Nonatherothrombotic coronary artery disease.

Ulrik Baandrup and Ingrid Bayer Kristensen.

Microvascular disease.

Hans Erik Bøtker.

Systemic causes of compromised supply.

Kavita Kumar.

Transplant vasculopathy.

Samir R. Kapadia and E. Murat Tuzcu.

Traumatic coronary artery disease.

Juan A. Asensio, Eric J. Kuncir, Patrizio Petrone and Tamer Karsidag.

6. Myocardial Ischemia: Morbid Demand.

Cardiac hypertrophy.

K-Raman Purushothaman, William N. O’Connor, Dario Echeverri and Pedro R. Moreno.

Systemic causes of increased demand.

Kavita Kumar.

7. Detection of Coronary Artery Disease.

Diagnostic coronary angiography.

Jens Knudsen and Ulrik Abildgaard.

Quantitative coronary arteriography.

Johan H.C. Reiber, Joan C. Tuinenburg, Gerhard Koning and Bob Goedhart.

Magnetic resonance coronary angiography.

Robert Jan M. van Geuns.

Noninvasive multi-slice spiral computed tomography.

Koen Nieman and Pim J. de Feyter.

Intracoronary ultrasound.

Nico Bruining.

Coronary angioscopy.

Yasumi Uchida.

Intracoronary Doppler flow.

M. Voskuil and J.J. Piek.

Endothelial dysfunction.

K.E. Sørensen and D.S. Celermajer.

Electron-beam computed tomography: coronary calcium.

Axel Schmermund, Stefan Möhlenkamp and Raimund Erbel.

Vulnerable atherosclerotic plaques.

Erling Falk, Johannes A. Schaar and Morteza Naghavi.

8. Detection of Myocardial Ischemia and Infarction.


K.S. Channer.

Exercise testing.

Jonathan M. Hill and Adam D. Timmis.

Continuous vectorcardiographic monitoring.

Bjarne Linde Nørgaard.


Anders Kirstein Pedersen.


Henrik Egeblad.

Myocardial scintigraphy.

Anne Kaltoft and Morten Bøttcher.

Positron emission tomography.

Morten Bøttcher.

Magnetic resonance imaging.

Won Yong Kim and Eike Nagel.

Computed tomography.

Sriram Padmanabhan, Matthew J. Budoff and Prediman K. Shah.

Electromechanical mapping.

Hans Erik Bøtker.

Invasive hemodynamic monitoring.

Christian Lindskov Christiansen and Erik Sloth.

Biochemical marker.

Jan Ravkilde.

9. Stable Ischemic Syndromes.

Stable angina pectoris.

Jens Erik Nielsen-Kudsk.

Prinzmetal’s variant angina.

Joseph Aragon and Prediman K. Shah.

Cardiac syndrome X.

Hans Erik Bøtker.

10. Acute Coronary Syndromes.

Non-ST elevation acute coronary syndromes.

R.J. de Winter.

Acute myocardial infarction with ST segment elevation.

John K. French and Harvey D. White.

Out-of-hospital cardiac arrest and sudden cardiac death.

R.W. Koster.

Triggering of acute coronary syndromes.

Christian J. Mussap, James E. Muller and Geoffrey H. Tofler.

Ischemic Heart Disease.

11. Acute Myocardial Infarction: Complications.

Cardiogenic shock.

Søren Boesgaard and Jan Aldershvile.

Mechanical complications.

Henrik Egeblad.

Arrhythmias complicating acute myocardial infarction.

Miguel Valderrábano and C. Thomas Peter.

Other complications.

Ira Perry and Saibal Kar.

12. Acute Myocardial Infarction: Special Problems.

Right ventricular acute myocardial infarction.

Henning Rud Andersen.

Thrombolysis or primary angioplasty?.

Henning Rud Andersen.

Reperfusion injury.

Miguel Valderrábano and William Ganz.

Downstream (micro)embolization, slow flow, and no reflow.

Erling Falk and Leif Thuesen.

Age and acute myocardial infarction.

Wilbert S. Aronow.

Gender differences in acute myocardial infarction.

Johan Herlitz.

Diabetes and acute myocardial infarction.

Joseph Aragon and Prediman K. Shah.


Morten Bøttcher.

Acute myocardial infarction in normal coronary arteries.

Ira Perry and Saibal Kar.

13. Heart Attack: Management Strategy.


Jens Flensted Lassen.

Emergency Department.

Kristian Thygesen and Joseph S. Alpert.

Coronary Care Unit.

Kristian Thygesen and Joseph S. Alpert.


Mogens Lytken Larsen.

14. Silent Myocardial Ischemia.

Hans Mickley.

15. Chronic Arrhythmias and Conduction Disorders.

Anders Kirstein Pedersen.

16. Left Ventricular Dysfunction.

Heart failure.

John G.F. Cleland, Nikolay Nikitin, Farqad Alamgir and Andrew Clark.

Ischemic cardiomyopathy, hibernation, and viability.

Arend F.L. Schinkel, Jeroen J. Bax and Don Poldermans.

17. Percutaneous Coronary Intervention.

Indications, procedure, and technique.

Leif Thuesen.

Results and complications.

Sjoerd H. Hofma and Pim J. de Feyter.

Late restenosis.

Benno J. Rensing.

18. Coronary Artery Bypass Graft Surgery.

Procedures and indications.

Matthew J. Price.

Complications and outcomes.

Matthew J. Price and Steven S. Khan.

19. Ischemic Heart Disease: Special Problems.

Women and hormones.

Steve Lee and Steven S. Khan.

Diabetic atherogenic dyslipidemias.

Allan D. Sniderman.

Revascularization: percutaneous coronary intervention versus coronary artery bypass grafting.

David Tüller and Bernhard Meier.

Allograft coronary artery disease.

Henrik Egeblad.

Chronic refractory angina.

Michael C. Kim and Samin K. Sharma.

Ethnicity and cardiovascular disease.

Stephanie Ounpuu and Salim Yusuf.

Cardiovascular disease in chronic kidney disease.

Daniel E. Weiner and Mark J. Sarnak.

20. Primary Prevention.

Steve Lee and Noel Bairey Merz.

21. Genetics of Ischemic Heart Disease.

Anne Tybjærg-Hansen.

22. Stem Cell Therapy in Acute Myocardial Infarction.

Jens Kastrup.

23. Guidelines and Recommendations.

Steen E. Husted and Birgitte K. Ziegler.



  • Provides an indispensable straightforward guide to the recognition and management of ischaemic heart disease.

  • The concise and clinically oriented text has been written by more than 100 world authorities from 4 continents.

  • Contains over 450 colour & b/w illustrations showing all aspects of ischaemic heart disease.