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Lewis Acids in Organic Synthesis

Lewis Acids in Organic Synthesis

Hisashi Yamamoto (Editor)

ISBN: 978-3-527-61830-9

Apr 2008

1014 pages

Select type: O-Book


The use of Lewis acids in organic synthesis, especially in catalysis is one of the most rapidly developing fields in synthetic organic chemistry. In addition, Lewis acid catalysis is one of the key technologies for asymmetric synthesis, and combinatorial chemistry as well as for large-scale production.

Until now, pertinent information on these topics was scattered throughout the literature. Although review articles have appeared,it was difficult for the researcher to compare different methods based on Lewis acids. This two-volume handbook, edited and written by an outstanding team of experts in the field, fills this gap!

This book is based on a classification according to metal centre of these electron-deficient compounds, allowing an in-depth treatment of the characteristics, benefits and limitations of each class of acid. Extensive cross-referencing and a comprehensive index enables readers to quickly find the solution to their synthesis problem. The chemical community will welcome this as a source of inspiration and invaluable reference for daily work.

Li(I), Na(I), and K(I) Lewis Acids (S. Saito).

Mg(II) and Zn(II) Lewis Acids (Y. Motoyama & H. Nishiyama).

Achiral B(III) Lewis Acids (K. Ishihara).

Chiral B(III) Lewis Acids (K. Ishihara).

Achiral Al(III) Lewis Acids (T. Ooi & K. Maruoka).

Chiral Aluminum Lewis Acids in Organic Synthesis (W. Wulff).

Silicon(IV) Lewis Acids (M. Oishi).

Sn(II) and Sn(IV) Lewis Acids (K. Ishihara).

Preparation and Lewis-Acid-Promoted Addition Reactions of Allylic and Allenic Tin and Indium Reagents (J. Marshall).


Sb(III) and Sb(V) Lewis Acids (K. Ishihara).

Copper Lewis Acids in Organic Synthesis (M. Sibi & G. Cook).

Ag(I), Au(I) Lewis Acids (A. Yanagisawa).

Transition Metal Lewis Acids: From Vanadium to Platinum (E. Kündig & C. Saudan).

Titanium(IV) Lewis Acids (H. Urabe & F. Sato).

Chiral Ti(IV) Lewis Acids (K. Mikami & M. Terada).

Hf-Centered Lewis Acids in Organic Chemistry (K. Suzuki & S. Yamanoi).

Zirconium Lewis Acids (R. Hara & T. Takahashi).

Sc(III) Lewis Acids (S. Kobayashi).

Lanthanide Lewis Acids Catalysis (M. Shibasaki, et al.).

Polymer-Supported Metal Lewis Acids (S. Itsuno).


The wealth of information and the complete referencing readily justify a purchase. The clear discussion of modern concepts leads the way for exiting novel developments. It is fun to read this extensive coverage of an exciting field. (Prof. Dr. Andreas Gansauer, Kekule-Institut fur Organische Chemie und Biochemie)

"Hisashi Yamamoto and his colleagues have provided a comprehensive, concise and timely survey of one of the most rapidly developing and useful frontiers in organic synthesis. This 2 volume set is a significant reference tool for students and researchers interested in organic synthesis, asymmetric synthesis and catalysis." (Perkin Transactions, No.13, 2001)

" important and timely work and should certainly be in every major research library." (Journal of the American Chemical Society, Vol. 124, No. 6, 2002)