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Lipophilicity in Drug Action and Toxicology

Lipophilicity in Drug Action and Toxicology

Vladimir Pliska (Editor), Bernard Testa (Editor), Han van de Waterbeemd (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Hendrik Timmerman (Series Editor)

ISBN: 978-3-527-61499-8

Mar 2008

463 pages

Select type: O-Book

Description

In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts.

It offers a thorough and highly topical survey of this rapidly developing field of research. Color plates demonstrating structural aspects, a vast number of references, and the straightforward presentation of the material make this volume a invaluable tool for all researchers involved in drug design or in the investigation of drug action.
From the contents:
Lipophilicity: The empirical tool and the fundamental objective/
Lipophilicity: A history/
Thermodynamics of van der Waals and hydrophobic interactions/
Intramolecular interactions encoded in lipophilicity: their nature and significance/
Lipophilicity measurement by reversed-phase high performance liquid chromatography (RP-HPLC)/
Centrifugal partition chromatography for lipophilicity measurements/
Assessment of distribution - pH profiles/
Estimation of lipophilicty by reversed-phase thin layer chromatography/
The future of log P calculation/
Theoretical calculation of partition coefficients/
Cellular automata model of partitioning between liquid phases