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Magnetic Nanomaterials

Magnetic Nanomaterials

Challa S. S. R. Kumar (Series Editor)

ISBN: 978-3-527-32154-4

Sep 2009

672 pages

Select type: Hardcover

Out of stock



The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences.

Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest.

Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies.

VOLUME 4 - Magnetic Nanomaterials
This volume takes the reader on a tour showing how magnetic nanomaterials are used in the fields of diagnosis and therapy, as well as in tissue engineering and environmental applications.


List of Contributors.

Part One Biosensing and Diagnosis.

1 Nanomaterials-Based Magnetic Relaxation Switch Biosensors (Tom Lowery).

1.1 Introduction.

1.2 Superparamagnetic Nanoparticles.

1.3 Agglomeration-Based Sensing.

1.4 T2 Sensitivity of MRSW Particles.

1.5 Kinetics of Magnetic Relaxation Switch Biosensors.

1.6 Demonstrations of Magnetic Relaxation Switch Biosensors.

1.7 Methods Development.

1.8 Micro-NMR of Magnetic Relaxation Switch Biosensors.



2 Multiplexed Detection with Magnetic Nanoparticles (Robert Wilson).

2.1 Introduction.

2.2 Magnetism and Magnetic Particles.

2.3 Planar Arrays.

2.4 Rotating Discs.

2.5 Diagnostic Devices.

2.6 Bio-Barcode Assays Based on Magnetic Microspheres.

2.7 Spectrally Encoded Suspension Arrays of Magnetic Microspheres.

2.8 Summary and Conclusions.


3 Magnetophoretic Biosensing and Separation Using Magnetic Nanomaterials (Joo H. Kang, Young Ki Hahn, Kyu Sung Kim, and Je-Kyun Park).

3.1 Introduction.

3.2 Theory.

3.3 Magnetophoresis in Microfluidic Devices.

3.4 Magnetophoretic Biosensing.

3.5 Magnetophoretic Separation.

3.6 Concluding Remarks.



4 Magnetic Nanomaterials as MRI Contrast Agents (Yurii K. Gun’ko and Dermot F. Brougham).

4.1 Introduction.

4.2 Classification of Magnetic Nanomaterials Used for MRI Applications.

4.3 Coating and Surface Functionalization of Magnetic Nanoparticles.

4.4 Properties and Characterization of Magnetic Nanoparticle Suspensions.

4.5 Application of Magnetic Nanomaterials in MRI.

4.6 Summary and Future Outlook.


Part Two Diagnosis and Therapy.

5 Magnetic Nanomaterials for In Vivo and In Vitro Cancer Diagnostics (Kelly Y. Kim).

5.1 Introduction.

5.2 Physico-Chemical Properties of Magnetic Nanoparticles.

5.3 Surface Coating for Improved Biocompatibility and Bioavailability.

5.4 MRI for In Vivo Diagnostics.

5.5 MRI for the Monitoring of Treatment.

5.6 Application of Magnetic Nanoparticles in In Vitro Diagnostics.

5.7 Detection of Circulating Tumor Cells.

5.8 Aptamers as an Alternative to Antibodies.

5.9 Conclusions.


6 Magnetic Nanoparticles for Cancer Imaging and Therapy (Arutselvan Natarajan, Rajeswari Sundrarajan, and Sally J. DeNardo).

6.1 Introduction.

6.2 Synthesis and Surface Modifi cations of MNPs for Biological Applications.

6.3 Development of MNPs as Cancer Diagnosis and Imaging Agents.

6.4 MNPs Applied to Cancer Therapy.

6.5 Summary.


7 Core-Shell Magnetic Nanomaterials in Medical Diagnosis and Therapy (Marites P. Melancon and Chun Li).

7.1 Introduction.

7.2 Synthesis.

7.3 Applications: Magnetic Resonance Imaging.

7.4 Applications: Hyperthermia and Thermal Ablation.

7.5 Application: Drug Delivery.

7.6 Summary and Perspectives.



Part Three Tissue Engineering.

8 The Use of Magnetic Particles in Tissue Engineering (Sarah H. Cartmell and Jon Dobson).

8.1 Introduction.

8.2 Magnetic Particle Technology Used in Various Tissue Types.

8.3 Summary and Concluding Remarks.


Part Four Environmental Applications.

9 Magnetic Nanomaterials for Environmental Applications (Marvin G. Warner, Cynthia L. Warner, R. Shane Addleman, and Wassana Yantasee).

9.1 Introduction.

9.2 Synthesis and Functionalization of Magnetic Nanoparticles.

9.3 Magnetic Nanoparticles for the Separation and Detection of Analytes.

9.4 Summary and Future Perspective.



Part Five Biofunctionalization and Characterization.

10 Magnetic Core–Polymer Shell Nanoparticles: Synthesis and Biomedical Applications (Koon Gee Neoh, Lihan Tan, and En-Tang Kang).

10.1 Introduction.

10.2 Synthesis of Magnetic Nanoparticles.

10.3 Magnetic Nanoparticles with Polymeric Shell.

10.4 Encapsulation of Magnetic Nanoparticles in a Polymeric Matrix.

10.5 Future Perspectives.


11 Magnetosomes: Bacterial Biosynthesis of Magnetic Nanoparticles and Potential Biomedical Applications (Sarah S. Staniland).

11.1 Introduction.

11.2 Magnetic Nanoparticles for Medical Applications.

11.3 What Is Biomineralization? Biogenic Inorganic Materials.

11.4 Magnetosomes: Biomineralization in Magnetic Bacteria.

11.5 Progress and Applications of Novel Biomedical Magnetosome Materials.

11.6 The Future for Biomedical Magnetosomes.


12 Approaches to Synthesis and Characterization of Spherical and Anisometric Metal Oxide Magnetic Nanomaterials (Lorenza Suber and Davide Peddis).

12.1 Introduction.

12.2 Magnetism in Nanostructured Metal Oxides.

12.3 Synthesis Methods for Spherical and Anisometric Iron Oxide Nanomaterials.

12.3.1 Synthesis of Spherical and Anisometric Nanoparticles.

12.4 Correlations between Synthesis and Magnetic Behavior in Iron Oxide Nanomaterials.

12.5 Conclusions and Perspectives.

List of Abbreviations.


13 Approaches to the Synthesis and Characterization of Spherical and Anisotropic Magnetic Alloy Nanomaterials (Matthew S. Wellons and Charles M. Lukehart).

13.1 Introduction.

13.2 Magnetic Noble Metal Alloy Nanoparticles.

13.3 Magnetic Early Transition Metal Alloy Nanoparticles.

13.4 Summary and Future Perspectives.


14 Approaches to the Biofunctionalization of Spherical and Anisotropic Iron Oxide Nanomaterials (Christopher J. Thode and Mary Elizabeth Williams).

14.1 Introduction.

14.2 Magnetic Nanoparticle Synthesis.

14.3 Nanoparticle Functionalization.

14.4 Conclusions.


15 Characterization of Magnetic Nanoparticles Using Magnetic Force Microscopy (Gunjan Agarwal).

15.1 Introduction.

15.2 Development of MFM.

15.3 Comparison of MFM to Other Techniques.

15.4 Physical Principals of MFM.

15.5 Noise in MFM.

15.6 MFM Cantilevers and Probes.

15.7 Probe Calibration.

15.8 Resolution in MFM.

15.9 MFM for Magnetic Nanoparticles.

15.10 The Application of MFM in the Life Sciences.

15.11 Limitations in MFM.

15.12 Recent Developments in MFM.

15.13 Summary and Future Perspectives.


16 Cobalt Nanomaterials: Synthesis and Characterization (Zhihua Zhang, Tiejun Zhou, Meihua Lu, Allen Wei Choong Poh, and Seidikkurippu N. Piramanayagam).

16.1 Introduction.

16.2 The Characterization of Co Nanoparticles.

16.3 Synthesis of Cobalt-Based Nanoparticles.

16.4 Magnetic Properties of Co Nanoparticles.

16.5 Summary and Outlook.