Skip to main content

Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

José Luis Millan

ISBN: 978-3-527-60747-1

Dec 2006, Wiley-Blackwell

337 pages

Select type: E-Book

$175.99

Description

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers:

* The structure, regulation and expression of the AP genes
* The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes
* The phenotypic abnormalities of the different AP knockout mice
* Our current understanding of the in vivo role of the AP isozymes.

The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
PART I: GENE AND PROTEIN STRUCTURE
1 Gene Structure
2 Developmental Expression
3 Gene Regulation
4 Protein Structure and Functional Domains
5 Enzymatic Properties
6 Epitope Maps
PART II: IN VIVO FUNCTIONS
7 The In Vivo Role of TNAP
8 Knockout Mouse Models
PART III: AP EXPRESSION IN HEALTH AND DISEASE
9 APs as Physiological and Disease Markers
10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Isozymes
PART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY
11 Applications of Recombinant APs
12 Use of APs in Prodrug Converting Strategies
13 APs as Therapeutic Agents
14 APs in the Food Industry
15 Veterinary Uses of AP Determinations
16 Methodologies