DescriptionMedicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.
There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:
- a comprehensive treatment of plant, microbial, and animal natural products in one volume
- extensive use of chemical schemes with annotated mechanistic explanations
- cross-referencing to emphasize links and similarities
- boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action
Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.
What to Study.
What to Learn.
Conventions Regarding Acids, Bases, and Ions.
Some Common Abbreviations.
2. SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION MECHANISMS.
Primary and Secondary Metabolism.
The Building Blocks.
The Construction Mechanisms.
Alkylation Reactions: Nucleophilic Substitution.
Some Vitamins Associated with the Construction Mechanisms.
Elucidating Biosynthetic Pathways.
3. THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES.
Fatty Acid Synthase: Saturated Fatty Acids.
Unsaturated Fatty Acids.
Uncommon Fatty Acids.
Polyketide Synthases: Generalities.
Polyketide Synthases: Macrolides.
Macrolide Antibiotics, Erythromycins, Oleandomycin and Spiramycin, Tylosin, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Rifamycins.
Polyketide Synthases: Linear Polyketides and Polyethers.
Polyketide Synthases: Aromatics.
Senna, Hypericum / St John?s Wort, Mycophenolic acid, Khellin and Cromoglicate, Griseofulvin.
Poison Ivy and Poison Oak, Cannabis, Aflatoxins, Tetracyclines, Anthracycline Antibiotics.
4. THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS.
Aromatic Amino Acids and Simple Benzoic Acids.
Cinnamic Acids and Esters.
Lignans and Lignin.
Benzoic Acids from C6C3 Compounds.
Flavonoids and Stilbenes.
5. THE MEVALONATE AND METHYLERYTHRITOL PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS.
Mevalonic Acid and Methylerythritol Phosphate.
Artemisinin, Gossypol, Trichothecenes.
Stereochemistry and Nomenclature.
Semi-Synthesis of Corticosteroids.
Alkaloids Derived from Ornithine.
Alkaloids Derived from Lysine.
Alkaloids Derived from Nicotinic Acid.
Alkaloids Derived from Tyrosine.
Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids.
Modified Benzyltetrahydroisoquinoline Alkaloids.
Terpenoid Tetrahydroisoquinoline Alkaloids.
Alkaloids Derived from Tryptophan.
Simple Indole Alkaloids.
Simple - Carboline Alkaloids.
Terpenoid Indole Alkaloids.
Alkaloids Derived from Anthranilic Acid.
Alkaloids Derived From Histidine.
Alkaloids Derived by Amination Reactions.
7. PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES.
Peptides and Proteins.
Ribosomal Peptide Biosynthesis.
Hormone, Growth Hormone-releasing Hormone/Factor, Somatostatin.
Anterior Pituitory Hormones.
Posterior Pituitory Hormones.
Ribosomal Peptide Toxins.
Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Conotoxins, Snake Venoms, Gila Monster Venom.
Nonribosomal Peptide Biosynthesis.
Bacitracins, Capreomycin, Polymyxins, Daptomycin, Cyclosporins, Vancomycin and Teicoplanin, Bleomycin, Streptogramins, Dactinomycin, Cycloserine.
Modified Peptides: Penicillins, Cephalosporins and Other ?-Lactams.
Aminosugars and Aminoglycosides.
Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin.
- Rapid advances have been made in the last decade in gene isolation and genetic engineering, leading to the elaboration of many biosynthetic pathways. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these new developments and other advances in the field
"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis." (Journal of Medicinal Chemistry, August 2009)
"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products." (Education in Chemistry, September 2009)
- Provides a comprehensive treatment of plant, microbial, and animal natural products in one volume
- Students’ skills in deductive reasoning are developed by emphasizing the relationships between classes of natural products rather than the more traditional descriptive approach
- Extensive further reading suggestions at the end of each chapter
- Boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action
- Extensive use of chemical schemes with annotated mechanistic explanations
- Includes cross-referencing to emphasize links and similarities