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Melanins and Melanosomes: Biosynthesis, Structure, Physiological and Pathological Functions

Melanins and Melanosomes: Biosynthesis, Structure, Physiological and Pathological Functions

Jan Borovansky (Editor), Patrick A. Riley (Editor)

ISBN: 978-3-527-63615-0

Jul 2011, Wiley-Blackwell

429 pages


The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.
The History of Melanosome Research (Jan Borovansky)
Classical and non-classical melanocytes in vertebrates (Sophie Colombo, Irina Berlin, Véronique Delmas, and Lionel Larue)
The Biological Chemistry of ortho-Quinones (Patrick A. Riley, Christopher A. Ramsden, and Edward J. Land)
Biosynthesis of Melanins (José Carlos García-Borrón, and M. Conchita Olivares Sánchez)
Inhibitors and Enhancers of Melanogenesis (Alain Taïeb, Muriel Cario-André, Stefania Briganti, and Mauro Picardo)
Structure of Melanins (Shosuke Ito, Kazumasa Wakamatsu, Marco d Ischia, Alessandra Napolitano, and Alessandro Pezzella)
Properties and Functions of Ocular Melanins and Melanosomes (Malgorzata Rózanowska)
The biological role of neuromelanin in the human brain and it's importance in Parkinson's disease (K. L. Double, W. Maruyama, M. Naoi, P. M. Gerlach and P. Riederer)
The Biogenesis of Melanosomes (Cédric Delevoye, Francesca Giordano, Michael S. Marks, and Graça Raposo)
The Transport and Distribution of Melanosomes (Mireille Van Gele and Jo Lambert)
Genetics of Melanosome Structure and Function (Vincent J. Hearing)
Physiological and Pathological Functions of Melanosomes (Jan Borovansky, Patrick A. Riley)
Dysplastic Naevi as Precursor Melanoma Lesions (Stanislav Pavel, Nico P.M. Smit, Karel Pizinger)