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Gregory R. Bock (Editor), Julie Whelan (Editor)

ISBN: 978-0-470-51374-3 April 2008 266 Pages


An international group of researchers addresses basic mechanism involved in the metastatic spread of tumors and considers new methods of prevention and treatment. Compares behavior of normal and abnormal cells, with emphasis on cell surface mechanisms--especially invasive processes--and inhibitors that might prevent metastasis. Also discusses determination of the metastatic genotype, the role of the immune system, and reduction of metastasis via liposome-activated macrophages.
Partial table of contents:

Tissue Organizational Stability and Intercellular Invasion (P. Armstrong).

Adhesion Mechanisms in Embryogenesis and in Cancer Invasion and Metastasis (J. Thiery, et al.).

The Cell Interaction Sites of Fibronectin in Tumor Metastasis. (M. Humphries, et al.).

Oncogene Induction of Metastases (L. Liotta).

Adhesive Properties of Metastasizing Tumor Cells (A. Raz).

Clonal Changes in Tumors During Growth and Progression Evaluated by Southern Gel Analysis of Random Integrations of Foreign DNA (R. Kerbel, et al.).

The Reversal of the Metastatic Phenotype by Gene Transfer (M. Feldman, et al.).

Inhibitors of Collagenase IV and Cell Adhesion Reduce the Invasive Activity of Malignant Tumor Cells (R. Reich, et al.).

Macrophage Therapy of Cancer Metastasis (I. Fidler).

Index of Contributors.

Subject Index.