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Molecular Control of Haemopoiesis

Molecular Control of Haemopoiesis

Gregory R. Bock (Editor), Joan Marsh (Editor)

ISBN: 978-0-470-51388-0

Sep 2007

242 pages

Select type: O-Book


The many different kinds of blood cells found in the human body are derived from multi-potential stem cells, which are induced to differentiate into one or another cell type by the action of regulatory proteins or growth factors. This volume looks at the way that binding of these proteins to specific receptors causes changes in gene expression in the nucleus and the activity of certain enzymes in the cytoplasm, committing the cell to a particular developmental pathway. Also discussed are recently established clinical applications and clinical trials of new techniques.
Partial table of contents:

The Proteins That Control Hemopoiesis and Leukemia (L. Sachs).

Protein Factors That Regulate the Growth and Differentiation of Mouse Myeloid Leukemia Cells (M. Hozumi, et al.).

Responses of Neutrophils to Myeloid Growth Factors (D. Golde, et al.).

Signal-Response Coupling Mediated by the Transduced Colony-Stimulating Factor-1 Receptor and Its Oncogenic fms Variants in Naive Cells (C. Sherr, et al.).

Hemopoietic Growth Factor Regulation of Protein Kinases and Genes Associated with Cell Proliferation (W. Farrar, et al.).

Contributions of Autocrine and Non-Autocrine Mechanisms to Tumorigenicity in a Murine Model for Leukemia (A. Dunn & A. Wilks).

Retroviral Infection and Hemopoiesis (J. Groopman).

The Use of Recombinant Human Erythropoietin in Humans (J. Adamson & J. Eschbach).

General Discussion.

Index of Contributors.

Subject Index.