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Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins

Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins

Rainer Fischer (Editor), Stefan Schillberg (Editor)

ISBN: 978-3-527-60363-3

Jun 2005, Wiley-Blackwell

338 pages

Description

Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels.
Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.
INTRODUCTION

PLANT PRODUCTION TECHNOLOGIES
Perennial plants as a production system for pharmaceuticals
Foreign protein expression using hairy roots and plant suspension cultures
Production of recombinant proteins in germinating seeds
Viral expression vectors
Field trials
Chloroplast derived antibodies, biopharmaceuticals and edible vaccines
sIgA production in plants
Antibodies in plants and plant cell suspension cultures


Production of spider silk proteins in plants
Glycosylation of plant produced proteins
The precautionary approach to tackle the wicked problems
Requirements and expectations of Molecular Farming from the view of big pharma
Choice of crop species and improving recombinant protein levels
Gene farming in pea under field conditions: Seed specific synthesis of a bacterial exoenzyme

“The book will be useful for molecular biologists and protein biochemists in academia and industry with an interest in molecular pharming and for anyone interested in obtaining a quick overview of the state of the field.”  (Annals of Botany, 1 October 2005)

"Authors from academia and industry provide a fascinating overview of current production technologies and possible future applications."
Bioworld

"... a valuable introduction. ... This volume, although aimed at a scientific audience, can be regarded as an early indication of a coming debate... Each chapter is concise but they all have many references ... I recommend this book."
Chemistry & Industry

"... this is an excellent book on this exciting new subject." American Journal of Therapeutics

"... covers a large amount of highly detailed material in a clear and concise manner."
Drug Development and Industrial Pharmacy