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Molecular Immunotoxicology

Molecular Immunotoxicology

Emanuela Corsini (Editor), Henk Van Loveren (Editor)

ISBN: 978-3-527-67699-6

Aug 2014

352 pages



The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered.
Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models.
Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
The Evolution of Immunotoxicology
Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity
Use of Toxicogenomics in Immunotoxicology
Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins
Chemical allergen-induced skin cell activation
The Aryl Hydrocarbon Receptor (AHR) as a Mediator of Adverse Immune Reactions
Immunotoxicological Effects of Pharmaceuticals on Signal Transduction in Innate and Adaptive Immunity
Promises and challenges with immunomodulatory biologics
The Non-Clinical Evaluation of Biotechnology-Derived Pharmaceuticals, Moving on after the TeGenero case
Glucocorticoid-Induced Immunomodulation
Particulate matter-induced immune activation
Genotoxic Mechanisms of PAH-Induced Immunotoxicity
Immunotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action
Pesticide-Induced Immunotoxicity: Molecular Targets
Mode of Action of Organotins in Immune Cells