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Myocardial Laser Revascularization

Myocardial Laser Revascularization

Charles Bridges (Editor), Keith Horvath (Editor), Ray Chu-Jeng Chiu (Editor)

ISBN: 978-0-470-99482-5

Apr 2008, Wiley-Blackwell

184 pages



Finally, there is a dependable guide to transmyocardial laser revasculariztion (TMR). In this groundbreaking volume, clinicians who pioneered the use of this innovative treatment share their insights on the indications, results, mechanisms, and limitations of the technique.

Under the careful editorial guidance of Drs. Bridges, Horvath, and Chiu, contributing authors explain:

  • the evolution, science, rationale, and limitations for TMR
  • how to select suitable candidates
  • anesthetic considerations and the role of transesophageal echo
  • TMR as a sole or combination therapy

Whether you are already practicing TMR or contemplating its addition to your therapeutic armamentarium, this concise reference will answer all your questions about this important new procedure.

List of Contrbutors.


1 Scientific and Historic Precedents.

(OH Frazier, Marianne Bergheim, and Kamuran A. Kadipasaoglu).

2 Laser-tissue Interaction.

(E. Duco Jansen and Peter Whittaker).

3 The biology of Laser-Tissue Interactions: in Vivo Comparisons and Consequences. (Peter Whittaker and E. Duco Jansen).

4 Histopathologic Effects of Transmyocardial Laser Revascularization on Myocardium: Assessment of Channel Patency.

(Kamuran A. Kadipasaoglu, Egemen Tuzun, and OH Frazier).

5 Animal Models of Acute and Chronic Coronary Ischemia: Effects of TMR on Perfusion and Left Ventricular Function.

(G. Chad Hughes and James E. Lowe).

6 Selection Criteria for Sole Therapy and Adjunctive Therapy in Combination with Coronary Artery Bypass Graft Surgery.

(Charles R. Bridges and Kapil Gopal).

7 Results of Prospective Randomized Trials.

(Keith B. Allen and Keith A Horvath).

8 Combination Therapy with Coronary Artery Bypass Grafting.

(Kapil Gopal and Charles R. Bridges).

9 Operative Techniques of Transmyocardial Laser Revascularization.

(Keith A. Horvath).

10 The Open Channel Hypothesis for Transmyocardial Revascularization: a Re-examination. (Peter Whittaker and Chad E. Darling).

11 Mechanisms of TMR: Angiogenesis. (Marc P Pelletier, Varun Kapila, and Ray CJ Chiu).

12 Myocardial Sinusoids and Non-compaction: Embryology and Relevance to the Adult Coronary Circulation. (Ray C.J. Chiu, Stephen J. Korkola, and Kevin Lachapelle).

13 Remodeling of the Intrinsic Cardiac Nervous System Following Chronic Transmyocardial Laser Therapy. (J. Andrew Armour).


Review Published on Doody's--December 2006:

"...covers the current state-of-the-art of myocardial laser revascularization, comprehensively reviewing the history, biology, clinical indications and results, and mechanisms of this technology.

The monograph is written for surgeons interested in laser revascularization. The authors are all recognized experts in the field.

The book presents a strong case for this technology and a superb review of the literature.

...a well-written book on a technology that continues to attract interest, although not many patient referrals, after over a decade of clinical experience...useful to surgeons with a keen interest in the subject..."

Ralph J. Damiano, MD(Washington University School of Medicine)

Myocardial Laser Revascularization is your dependable guide to TMR

This reference is the first to cover:

  • the evolution, science, and rationale for TMR, as well as how to recognize suitable candidates

  • TMR as a sole or combination therapy

  • anesthetic considerations and the role of transesophageal echo