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Nanotoxicity: From In Vivo and In Vitro Models to Health Risks



Nanotoxicity: From In Vivo and In Vitro Models to Health Risks

Saura C. Sahu (Editor), Daniel A. Casciano (Co-Editor)

ISBN: 978-0-470-74137-5 October 2009 630 Pages

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Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials.

Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include:

  • biomarkers for nanotoxicity assessment
  • nanotoxicity assessment by gene expression analysis
  • in vivo and in vitro models for nanotoxicity testing
  • mechanisms of nanotoxicity
  • pharmakokinetics of nanomaterials
  • nanotoxicity of foods including food processing, food packaging and food safety
  • nanotoxicity of drugs including drug development and drug delivery
  • nanotoxicity of cosmetics and consumer products
  • health and environmental impact of nanotoxicity
  • safety evaluation of nanomaterials
  • regulatory impact of nanomaterials

Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

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List of Contributors.


1 Characterization of Nanomaterials for Toxicological Evaluation (Kevin W. Powers, Maria Palazuelos, Scott C. Brown and Stephen M. Roberts).

2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies (Christie M. Sayes and David B. Warheit).

3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines (Lea Ann Dailey).

4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm (Craig A. Poland, Rodger Duffin and Ken Donaldson).

5 Application of Zinc Oxide Quantum Dots in Food Safety (Tony Jin, Dazhi Sun, Howard Zhang and Hung-Jue Sue).

6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo (Jinsong Zhang).

7 Evaluation of Toxicity of Nanostructures in Biological Systems (Adam J. Gormley and Hamidreza Ghandehari).

8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials (David B. Warheit, Kenneth L. Reed and Christie M. Sayes).

9 Nanoparticles: Is Neurotoxicity a Concern? (Jianyong Wang, Wenjun Sun and Syed F. Ali).

10 Hepatotoxic Potential of Nanomaterials (Saura C. Sahu).

11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets (Jan Simak).

12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment (David S. Barber, Nancy D. Denslow, R. Joseph Griffitt and Christopher J. Martyniuk).

13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo (Weiyue Feng, Bing Wang and Yuliang Zhao).

14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity (Ken-ichiro Inoue and Hirohisa Takano).

15 In Vivo and In Vitro Models for Nanotoxicology Testing (Rosalba Gornati, Elena Papis, Mario Di Gioacchino, Enrico Sabbioni, Isabella Dalle Donne, Aldo Milzani and Giovanni Bernardini).

16 In Vitro and In Vivo Toxicity Study of Nanoparticles (Jayoung Jeong, Wan-Seob Cho, Seung Hee Kim and Myung-Haing Cho).

17 In Vitro and In Vivo Models for Nanotoxicity Testing (Kyung O. Yu, Laura K. Braydich-Stolle, David M. Mattie, John J. Schlager and Saber M. Hussain).

18 In Vitro Models for Nanotoxicity Testing (Yinfa Ma).

19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles (Fabian Blank, Peter Gehr and Barbara Rothen-Rutishauser).

20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms (Thomas R. Pisanic, Sungho Jin and Veronica I. Shubayev).

21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment (David Y. Lai and Philip G. Sayre).

22 Evaluating Strategies For Risk Assessment of Nanomaterials (Nastassja Lewinski, Huiguang Zhu and Rebekah Drezek).

23 Strategies for Risk Assessment of Nanomaterials (Hae-Seong Yoon, Hyun-Kyung Kim, Dong Deuk Jang and Myung-Haing Cho).

24 Metal Nanoparticle Health Risk Assessment (Mario Di Gioacchino, Nicola Verna, Rosalba Gornati, Enrico Sabbioni and Giovanni Bernardini).

25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products (J.S. Tsuji, F.S. Mowat, S. Donthu and M. Reitman).

26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials (Penelope A. Rice, Kimberly S. Cassidy, Jeremy Mihalov and T. Scott Thurmond).


"I can certainly envisage this book being used widely. Indeed, an excellent and most timely book, clearly written, and sensitively related to nano; above all, it really 'speaks' to the realities of nanotoxicity. An additional important one at that.... Is .the list of references cited at the end of every contribution that must make the acquisition of the volume urgent and imperative." (Current Engineering Practice, 2010)