Skip to main content


Neural Tube Defects

Gregory R. Bock (Editor), Joan Marsh (Editor)

ISBN: 978-0-470-51456-6 April 2008 310 Pages


Neural tube defects are the second most common cause of perinatal death from birth defects in the United Kingdom. In this important book, leading scientists evaluate the latest evidence on the causative factors--both genetic and environmental--of these major human congenital malformations. They also discuss prospects for early detection by prenatal screening and for treatment both before and after birth. The extensive coverage encompasses such topics as: formation and patterning of the avian neuraxis, neurulation in mammals and the normal human embryo, folic acid and more.
Partial table of contents:

Normal Neurulation in Amphibians (A. Jacobson).

Formation and Patterning of the Avian Neuraxis: One Dozen Hypotheses (G. Schoenwolf).

Molecular Genetics of Neurulation (N. Papalopulu & C. Kintner).

Valproic Acid-Induced Neural Tube Defects (H. Nau).

Folic Acid Metabolism and Mechanisms of Neural Tube Defects (J. Scott, et al.).

Folic Acid and Neural Tube Defects: The Current Evidence and Implications for Prevention (N. Wald).

Spina Bifida: Anticonvulsants and Other Maternal Influences (L. Holmes).