1. LC-NMR: Theory and Experiment (Klaus Albert).
1.2 NMR in a Flowing Liquid.
1.3 Design of Continuous-Flow NMR Probes.
1.4 Experimental Arrangement for HPLC-1H NMR Coupling.
1.5 Practical Considerations, Solvent Suppression Techniques, Gradient Elution and Purity of HPLC Solvent.
2. LC-NMR: Automation (Ulrich Braumann and Manfred Spraul).
2.1 Practical Use of LC-NMR and LC-NMR/MS.
2.2 Different Working Modes in LC-NMR.
2.3 Use of Mass Spectrometry in the Set-Up.
2.4 Measurement Procedures.
3. Biomedical and Pharmaceutical Applications of HPLC-NMR and HPLC-NMR-MS (John C. Lindon, Jeremy K. Nicholson and Ian D. Wilson).
3.2 Technical and Operational Overview.
3.3 Applications in Combinatorial Chemistry.
3.4 Application to Chemical Impurities.
3.5 Application to Chiral Separations of Pharmaceutical Mixtures.
3.6 Application to Natural Products.
3.7 Application to Chemical Reactivity of Drug Glucuronides.
3.8 Application to Futile Deacetylation Reactions.
3.9 Application to Trapping of Reactive Intermediates.
3.10 Application to Uptake and Transformation of Xenobiotics by Plants.
3.11 Separation of Lipoproteins and their Characterisation using HPLC-NMR.
3.12 Superheated-Water HPLC-NMR and HPLC-NMR-MS Studies on Pharmaceuticals.
3.13 Application of Hypernation to a Mixture of Non-Steroidal Anti-Inflammatory Drugs.
3.14 Concluding Remarks.
4. Application of On-Line LC-NMR and Related Techniques to Drug Metabolism Studies (John P. Shockcor).
4.2 LC-NMR Techniques.
4.3 Application of LC-NMR-MS to Drug Metabolism: The Structure Elucidation of Rat Urinary Metabolites of Efavirenz by LC-NMR-MS.
5. LC-NMR for Natural Products Analysis.
5.1 Application of LC-NMR and LC-NMR-MS Hyphenation to Natural Products Analysis (Martin Sandvoss).
5.2 Hyphenation of Modern Extraction Techniques to LC-NMR for the Analysis of Geometrical Carotenoid Isomers in Functional Food and Biological Tissues (Tobias Glaser and Klaus Albert).
6. LC-NMR in Environmental Analysis (Alfred Preiss and Markus Godejohann).
6.2 Target and Non-Target Analysis.
6.3 LC-NMR Coupling in Non-Target Analysis.
6.4 Application of LC-NMR and LC-NMR in Combination with LC-MS to Environmental Samples.
6.5 Simulation of Environmental Processes.
7. Related Techniques -
7.1 GPC-NMR Coupling (Heidrun Händel and Klaus Albert).
7.2 SFC-NMR and SFE-NMR (Holger Fischer and Klaus Albert).
7.3 Nanoliter NMR.
8. Future Developments -
8.1 HPLC-13C NMR (Klaus Albert).
8.2 Parallel NMR Detection (Andrew G. Webb, Jonathan V. Sweedler and Daniel Raftery).
Concluding Remarks (Klaus Albert).
""...this is a stimulating book, written by experts in the field, with a state-of-the-art presentation ..."" (Chromatographia, May 2003)
""...the best compilation of LC-NMR knowledge and related techniques to date and therefore is a must for anyone who wants to use this methodology to solve everyday analytical problems."" (Journal of the American Chemical Society, Vol. 125, No. 21, 2003)
""...this fascinating book is an invaluable reference source for researchers..."" (Angewandte Chemie, International Edition, Vol. 42)
""...an invaluable reference source for researchers...gives a comprehensive overview of the basis and the current applications..."" (Angewandte Chemie, 2003)
""...a stimulating book, written by experts in the field...an indispensable tool in bio-related research..."" (Chromatographia, 2003)
""…well written and informative…"" (Anal. Bioanal. Chem. 2004;379)