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Organic Chemistry: Breakthroughs and Perspectives

Organic Chemistry: Breakthroughs and Perspectives

Kuiling Ding (Editor), Li-Xin Dai (Editor)

ISBN: 978-3-527-32963-2 September 2012 853 Pages

 Paperback

In Stock

$133.00

Description

This helpful, useful, practical book presents the most important achievements in organic chemistry over the past decade, summarizing such major developments as C-H activation, organocatalysis, and supramolecular chemistry. Each chapter contains two or three personal, hitherto unpublished, commentaries by leading experts on the topic. This reference work focuses on four main areas: the total synthesis of natural products and chemical biology; synthetic methodology; physical organic chemistry and chemistry relevant to meeting the urgent needs of humanity. The result is a complete and extremely useful source of a wide variety of information for graduate students, post-docs and researchers.
INTRODUCTION

DIVERSITY-ORIENTED SYNTHESES OF NATURAL PRODUCTS AND NATURAL PRODUCT-LIKE COMPOUNDS
Introduction
Diversity-Oriented Synthesis (DOS)
Diverted Total Synthesis (DTS)
Function-Oriented Synthesis (FOS)
Target-Oriented Synthesis (TOS)
Conclusion and Perspectives

TOTAL SYNTHESIS OF NATURAL PRODUCTS AND THE SYNERGY WITH SYNTHETIC METHODOLOGY
Introduction
Domino Process
Multicomponent Reactions
Oxidative Anion Coupling
Pattern Recognition
Conformation-Directed Cyclization
Conclusion and Perspectives

INTERPLAY BETWEEN THE CHEMICAL SPACE AND THE BIOLOGICAL SPACE
Chemical Biology: Historical and Philosophical Aspects
Preparation of Chemical Libraries
Screening Strategies
Target Elucidation and Validation
Conclusion and Perspectives

BIOSYNTHESIS OF PHARMACEUTICAL NATURAL PRODUCTS AND THEIR PATHWAY ENGINEERING
Introduction
Expanded Paradigms in Biosynthetic Logic
New Approaches to NP Biosynthesis Research
Better Understanding of the Scope and Diversity of NP Production
Future Perspectives

CARBOHYDRATE SYNTHESIS TOWARDS GLYCOBIOLOGY
Introduction
Advances in Chemical Glycosylation
New Strategies in Oligosaccharide Assembly
Enzymatic and Chemoenzymatic Methods
Synthesis of Heparin and Heparan Sulfate Oligosaccharides
Synthesis of Homogeneous Glycoproteins
Synthesis of Carbohydrate-Containing Complex Natural Compounds
Conclusion and Perspectives

CHEMICAL SYNTHESIS OF PROTEINS
Introduction
Brief History
Current Technology
Applications
Conclusion and Perspectives

CUAAC: THE QUINTESSENTIAL CLICK REACTION
Introduction
Azide -
Alkyne Cycloaddition: the Basics
CuAAC: Catalysts and Ligands
Mechanistic Aspects of the CuAAC
Reactions of 1-Iodoalkynes
Examples of Application of the CuAAC Reaction
Reactions of Sulfonyl Azides
Outlook/Perspective

TRANSITION METAL-CATALYZED C -
H FUNCTIONALIZATION: SYNTHETICALLY ENABLING REACTIONS FOR BUILDING MOLECULAR COMPLEXITY
Introduction
Background and Early Work
First Functionalization: Challenges in Hydrocarbon Chemistry
Further Functionalization: C -
H Bonds as Reaction Partners in Organic Synthesis
Catalytic C -
H Functionalization via Metal Insertion
Other Emerging Metal-Catalyzed Further Functionalization Methods
Outlook and Conclusion

AN OVERVIEW OF RECENT DEVELOPMENTS IN METAL-CATALYZED ASYMMETRIC TRANSFORMATIONS
Introduction
Asymmetric Carbon -
Carbon Bond Formation
Asymmetric Reductions and Oxidations
Conclusion

THE PROLINE-CATALYZED MANNICH REACTION AND THE ADVENT OF ENAMINE CATALYSIS
Introduction
The Proline-Catalyzed Mannich Reaction
Conclusion

RECENT TOPICS IN COOPERATIVE CATALYSIS: ASYMMETRIC CATALYSIS, POLYMERIZATION, HYDROGEN ACTIVATION, AND WATER SPLITTING
Introduction
Cooperative Catalysis in Asymmetric Reactions
Cooperative Catalysis in Alkene Polymerization
Cooperative Catalysis in Hydrogen Activation/Generation
Conclusion and Perspectives

FLOURISHING FRONTIERS IN ORGANOFLUORINE CHEMISTRY
Introduction
Synthetic Approaches for the Introduction of Fluorine-Containing Functionalities and Related Chemistry
Conclusion and Perspectives

SUPRAMOLECULAR ORGANIC CHEMISTRY: THE FOLDAMER APPROACH
Introduction
Foldamers: the Background
Molecular Recognition
Homoduplex
Organogels
Vesicles
Supramolecular Liquid Crystals
Macrocycles
Catalysis
Macromolecular Self-Assembly
Conclusion and Perspectives

NOVEL CATALYSIS FOR ALKENE POLYMERIZATION MEDIATED BY POST-METALLOCENES: A GATEWAY TO NEW POLYALKENES
Introduction
Late Transition Metal Complexes
Early Transition Metal Complexes
Conclusion and Perspectives

CHEMISTRY COMPUTATIONALLY AND EXPERIMENTALLY: HOW WILL COMPUTATIONAL ORGANIC CHEMISTRY IMPACT ORGANIC THEORIES, MECHANISMS, AND SYNTHESIS IN THE TWENTY-FIRST CENTURY?
Introduction
Developing New Theories, Concepts, and Understandings for Organic Chemistry
Understanding Reaction Mechanisms
Computation-Guided Development of New Catalysts, New Reactions, and Synthesis Planning for Ideal Synthesis
Conclusion

CASE STUDY OF MECHANISMS IN SYNTHETIC REACTIONS
Introduction
Mechanistic Study of Coupling Reactions
Mechanistic Study of Aerobic Oxidation
Conclusion and Perspective

ORGANIC MATERIALS AND CHEMISTRY FOR BULK HETEROJUNCTION SOLAR CELLS
Introduction
Molecular Design and Engineering of Donor Materials
Molecular Design and Engineering of Acceptor Materials
Conclusion and Outlook

CATALYTIC UTILIZATION OF CARBON DIOXIDE: ACTUAL STATUS AND PERSPECTIVES
Introduction
Catalytic Reductions of CO2 to Formic Acid and Methanol
CO2 as a C1-Building Block in C -
C Coupling Reactions
Catalytic C -
O Bond Formation Utilizing Carbon Dioxide
Current Industrial Processes Using CO2
Conclusion and Outlook

SYNTHETIC CHEMISTRY WITH AN EYE ON FUTURE SUSTAINABILITY
Introduction
Cross-Dehydrogenative Coupling
Nucleophilic Addition of Terminal Alkynes in Water
Conclusion and Perspectives

ORGANIC Pi-CONJUGATED MOLECULES FOR ORGANIC SEMICONDUCTORS AND PHOTOVOLTAIC MATERIALS
Introduction
Conjugated Molecules for p-Type Organic Semiconductors
Conjugated Molecules for n-Type Organic Semiconductors
Conjugated Molecules for Photovoltaic Materials
Conclusion and Outlook

THE FUTURE OF ORGANIC CHEMISTRY -
AN ESSAY
Introduction
The Field of Organic Chemistry Will Broaden
Conclusion

“This volume, though oriented primarily to major developments in synthesis and chemical biology, with relatively little attention to topics in physical organic chemistry such as nonclassical carbocations, is a valuable resource for all academic and professional chemistry collections. Summing Up: Highly recommended. Lower-division undergraduates and above."  (Choice, 1 July 2013)